![]() clindamycin hydrochloride structure
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Common Name | clindamycin hydrochloride | ||
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CAS Number | 58207-19-5 | Molecular Weight | 479.459 | |
Density | N/A | Boiling Point | 647ºC at 760 mmHg | |
Molecular Formula | C18H36Cl2N2O6S | Melting Point | 143ºC | |
MSDS | Chinese USA | Flash Point | 345.1ºC |
Use of clindamycin hydrochlorideClindamycin hydrochloride monohydrate is an oral protein synthesis inhibitory agent that has the ability to suppress the expression of virulence factors in Staphylococcus aureus at sub-inhibitory concentrations (sub-MICs). Clindamycin hydrochloride monohydrate resistance results from enzymatic methylation of the antibiotic binding site in the 50S ribosomal subunit (23S rRNA). Clindamycin hydrochloride monohydrate decreases the production of Panton-Valentine leucocidin (PVL), toxic-shock-staphylococcal toxin (TSST-1) or alpha-haemolysin (Hla)[1]. |
Name | Clindamycin Hydrochloride Monohydrate |
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Synonym | More Synonyms |
Description | Clindamycin hydrochloride monohydrate is an oral protein synthesis inhibitory agent that has the ability to suppress the expression of virulence factors in Staphylococcus aureus at sub-inhibitory concentrations (sub-MICs). Clindamycin hydrochloride monohydrate resistance results from enzymatic methylation of the antibiotic binding site in the 50S ribosomal subunit (23S rRNA). Clindamycin hydrochloride monohydrate decreases the production of Panton-Valentine leucocidin (PVL), toxic-shock-staphylococcal toxin (TSST-1) or alpha-haemolysin (Hla)[1]. |
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Related Catalog | |
References |
Boiling Point | 647ºC at 760 mmHg |
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Melting Point | 143ºC |
Molecular Formula | C18H36Cl2N2O6S |
Molecular Weight | 479.459 |
Flash Point | 345.1ºC |
Exact Mass | 478.167114 |
PSA | 136.79000 |
LogP | 1.45600 |
Index of Refraction | 143 ° (C=2, H2O) |
Water Solubility | Soluble in water |
Hazard Codes | Xi: Irritant; |
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Risk Phrases | 36/37/38 |
Safety Phrases | 26-37/39 |
RIDADR | NONH for all modes of transport |
RTECS | GF2275000 |
HS Code | 29419090 |
Performance characterization of a quantitative liquid chromatography-tandem mass spectrometric method for 12 macrolide and lincosamide antibiotics in salmon, shrimp and tilapia.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 967 , 203-10, (2014) This paper describes an extension and performance characterization of a quantitative confirmatory multi-residue liquid chromatography-tandem mass spectrometric method for residues of macrolide and lin... |
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Development of a method to quantify clindamycin in vitreous humor of rabbits' eyes by UPLC-MS/MS: application to a comparative pharmacokinetic study and in vivo ocular biocompatibility evaluation.
J. Pharm. Biomed. Anal. 102 , 346-52, (2015) Ocular toxoplasmosis may result in uveitis in the posterior segment of the eye, leading to severe visual complications. Clindamycin-loaded poly(lactide-co-glycolide) (PLGA) implants could be applied t... |
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A biodegradable antibiotic-impregnated scaffold to prevent osteomyelitis in a contaminated in vivo bone defect model.
Eur. Cell. Mater. 27 , 332-49, (2014) Open fractures are at risk of serious infection and, if infected, require several surgical interventions and courses of systemic antibiotics. We investigated a new injectable formulation that simultan... |
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