aspidin BB
Modify Date: 2024-01-04 11:31:31
aspidin BB structure
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Common Name | aspidin BB | ||
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| CAS Number | 584-28-1 | Molecular Weight | 460.51700 | |
| Density | 1.285g/cm3 | Boiling Point | 704.9ºC at 760mmHg | |
| Molecular Formula | C25H32O8 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 236.6ºC | |
Use of aspidin BBAspidin BB is a phloroglucinol derivative, which can be isolated from the aerial part of Dryopteris championii. Aspidin BB has anticancer activity. Aspidin BB induces cell cycle arrest and apoptosis in human ovarian HO-8910 cells[1][2]. |
| Name | 2-butanoyl-4-[(3-butanoyl-2,6-dihydroxy-4-methoxy-5-methylphenyl)methyl]-3,5-dihydroxy-6,6-dimethylcyclohexa-2,4-dien-1-one |
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| Synonym | More Synonyms |
| Description | Aspidin BB is a phloroglucinol derivative, which can be isolated from the aerial part of Dryopteris championii. Aspidin BB has anticancer activity. Aspidin BB induces cell cycle arrest and apoptosis in human ovarian HO-8910 cells[1][2]. |
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| Related Catalog | |
| Target |
Bcl-2 Bax Caspase-3 |
| In Vitro | Aspidin BB (0-100 μM, 24-72 h) 以剂量和时间依赖性方式显着抑制 HO-8910 细胞增殖。处理 72、48 和 24 小时后IC50值分别为 15.02、25.79 和 68.81 μM[1]。 Aspidin BB 抑制 Bcl-2 表达并增强 Bax 表达以破坏线粒体外膜，然后引起细胞色素 c 释放导致效应 caspase-3 激活，并进一步切割细胞核中的聚 ADP-核糖聚合酶 (PARP)，最终诱导细胞凋亡[1]。 Aspidin BB 通过上调 pRb、E2F1、CDK2、细胞周期蛋白 E 和细胞周期蛋白 A 蛋白在 HO-8910 细胞中引起 S 期阻滞[1]。 |
| References |
| Density | 1.285g/cm3 |
|---|---|
| Boiling Point | 704.9ºC at 760mmHg |
| Molecular Formula | C25H32O8 |
| Molecular Weight | 460.51700 |
| Flash Point | 236.6ºC |
| Exact Mass | 460.21000 |
| PSA | 141.36000 |
| LogP | 4.54240 |
| Index of Refraction | 1.594 |
| Aspidin VV |
| Aspidin |
| aspidin-BB |