Orciprenaline sulfate structure
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Common Name | Orciprenaline sulfate | ||
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CAS Number | 5874-97-5 | Molecular Weight | 520.59400 | |
Density | 1.199g/cm3 | Boiling Point | 417.5ºC at 760mmHg | |
Molecular Formula | C11H17NO3.1/2H2O4S | Melting Point | 202-203° | |
MSDS | Chinese USA | Flash Point | 179.7ºC | |
Symbol |
GHS07 |
Signal Word | Warning |
Use of Orciprenaline sulfateMetaproterenol hemisulfate (Orciprenaline hemisulfate) is a direct-acting sympathomimetic and a β2-adrenergic receptor (β2AR) agonist with an IC50 of 68 nM. Metaproterenol hemisulfate also has anti-inflammatory activity[1][2]. |
Name | Metaproterenol Hemisulfate Salt |
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Synonym | More Synonyms |
Description | Metaproterenol hemisulfate (Orciprenaline hemisulfate) is a direct-acting sympathomimetic and a β2-adrenergic receptor (β2AR) agonist with an IC50 of 68 nM. Metaproterenol hemisulfate also has anti-inflammatory activity[1][2]. |
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Related Catalog | |
Target |
IC50: 68 nM (β2-adrenergic receptor)[1] |
In Vitro | Metaproterenol (10 μM; 74 hours; THP-1 cells and bone marrow macrophages) treatment enhances β-arrestin2 and its interaction with IκBα in high glucose-induced THP-1 cells and bone marrow macrophages[1]. Metaproterenol (10 μM; 74 hours; THP-1 cells and bone marrow macrophages) treatment leads to downregulation of NF-κB in high glucose-induced THP-1 cells and bone marrow macrophages[1]. Western Blot Analysis[1] Cell Line: THP-1 cells and bone marrow macrophages Concentration: 10 μM Incubation Time: 74 hours Result: Enhanced β-arrestin2 and its interaction with IκBα. RT-PCR[1] Cell Line: THP-1 cells and bone marrow macrophages Concentration: 10 μM Incubation Time: 74 hours Result: Led to downregulation of NF-κB. |
In Vivo | Treatment of Zucker diabetic fatty rats with Metaproterenol for 12 weeks attenuates monocyte activation as well as pro-inflammatory and pro-fibrotic responses in the kidneys and heart. Thus, Metaproterenol might has protective effects against diabetic renal and cardiovascular complications[1]. |
References |
Density | 1.199g/cm3 |
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Boiling Point | 417.5ºC at 760mmHg |
Melting Point | 202-203° |
Molecular Formula | C11H17NO3.1/2H2O4S |
Molecular Weight | 520.59400 |
Flash Point | 179.7ºC |
Exact Mass | 520.20900 |
PSA | 228.42000 |
LogP | 3.46820 |
Water Solubility | Freely soluble in water, slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride. |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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Lipophilicity of amine neurotransmitter precursors, metabolites and related drugs estimated on various TLC plates.
J. Chromatogr. Sci. 52(9) , 1095-103, (2014) The retention behavior for a series of amine neurotransmitters, their precursors, metabolites and structurally related drugs has been investigated in reversed-phase thin-layer chromatography using RP-... |
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Stimulation by transforming growth factor-α of DNA synthesis and proliferation of adult rat hepatocytes in primary cultures: modulation by α- and β-adrenoceptor agonists. Kimura, M., et al.
J. Pharmacol. Exp. Ther. 29 , 171, (1999)
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Examination of the effects of increasing Gs protein on beta2-adrenergic receptor, Gs, and adenylyl cyclase interactions.
Biochem. Pharmacol. 54 , 61-72, (1997) We have examined the effect of increased Gs protein levels on the abilities of three different beta2-agonists to induce GTP shifts and stimulate adenylyl cyclase response in an effort to investigate t... |
Orciprenaline sulfate |