Licochalcone B

Modify Date: 2024-01-04 12:44:21

Licochalcone B Structure
Licochalcone B structure
 Common Name Licochalcone B
CAS Number 58749-23-8 Molecular Weight 286.279
Density 1.4±0.1 g/cm3 Boiling Point 550.5±50.0 °C at 760 mmHg
Molecular Formula C16H14O5 Melting Point 196-197ºC
MSDS N/A Flash Point 208.5±23.6 °C

 Use of Licochalcone B


Licochalcone B is an extract from the root of Glycyrrhiza inflate. Licochalcone B inhibits amyloid β (Aβ42) self-aggregation (IC50=2.16 μM) and disaggregate pre-formed Aβ42 fibrils, reduce metal-induced Aβ42 aggregation through chelating metal ions[1].

 Names

Name (E)-3-(3,4-dihydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one
Synonym More Synonyms

 Licochalcone B Biological Activity

Description Licochalcone B is an extract from the root of Glycyrrhiza inflate. Licochalcone B inhibits amyloid β (Aβ42) self-aggregation (IC50=2.16 μM) and disaggregate pre-formed Aβ42 fibrils, reduce metal-induced Aβ42 aggregation through chelating metal ions[1].
References

[1]. Cao Y, et al. Licochalcone B, a chalcone derivative from Glycyrrhiza inflata, as a multifunctional agent for the treatment of Alzheimer's disease. Nat Prod Res. 2018 Oct 22:1-4.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 550.5±50.0 °C at 760 mmHg
Melting Point 196-197ºC
Molecular Formula C16H14O5
Molecular Weight 286.279
Flash Point 208.5±23.6 °C
Exact Mass 286.084137
PSA 86.99000
LogP 2.57
Vapour Pressure 0.0±1.5 mmHg at 25°C
Index of Refraction 1.684
Storage condition 2-8C

 Synthetic Route

2,3,4-Trihydroxybenzaldehyde structure

2,3,4-Trihydrox...

CAS#:2144-08-3

~%

Licochalcone B Structure

Licochalcone B

CAS#:58749-23-8

Literature: Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 21, # 10 p. 965 - 966
(E)-3-(2-methoxy-3,4-bis(methoxymethoxy)phenyl)-1-(4-(methoxymethoxy)phenyl)prop-2-en-1-one structure

(E)-3-(2-methox...

CAS#:85699-02-1

~%

Licochalcone B Structure

Licochalcone B

CAS#:58749-23-8

Literature: Islam, Azizul; Khan, Saeed Ahmad; Krishnamurti, M. Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1982 , vol. 21, # 10 p. 965 - 966
1-[4-(methoxymethoxy)phenyl]ethanone structure

1-[4-(methoxyme...

CAS#:85699-00-9

~%

Licochalcone B Structure

Licochalcone B

CAS#:58749-23-8

Literature: Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 21, # 10 p. 965 - 966
2-hydroxy-3,4-bis(methoxymethoxy)benzaldehyde structure

2-hydroxy-3,4-b...

CAS#:85698-99-3

~%

Licochalcone B Structure

Licochalcone B

CAS#:58749-23-8

Literature: Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 21, # 10 p. 965 - 966
2-hydroxy-3,4,4'-tri(methoxymethoxy)chalkone structure

2-hydroxy-3,4,4...

CAS#:85699-01-0

~%

Licochalcone B Structure

Licochalcone B

CAS#:58749-23-8

Literature: Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 21, # 10 p. 965 - 966
4-Hydroxyacetophenone structure

4-Hydroxyacetop...

CAS#:99-93-4

~%

Licochalcone B Structure

Licochalcone B

CAS#:58749-23-8

Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 24, # 1 p. 181 - 185

 Synonyms

2-methoxy-3,4,4'-trihydroxychalcone
Licochalcone B
Licochalcon B
(2E)-3-(3,4-Dihydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)-2-propen-1-one
2-Propen-1-one, 3-(3,4-dihydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)-, (2E)-
licochalcone
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Chemsrc provides Licochalcone B(CAS#:58749-23-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Licochalcone B are included as well.>> amp version: Licochalcone B

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