Sulfaquinoxaline

Modify Date: 2024-01-02 19:41:05

Sulfaquinoxaline structure	Common Name	Sulfaquinoxaline
	CAS Number	59-40-5	Molecular Weight	300.336
	Density	1.5±0.1 g/cm3	Boiling Point	557.0±52.0 °C at 760 mmHg
	Molecular Formula	C₁₄H₁₂N₄O₂S	Melting Point	247-2480C
	MSDS	Chinese USA	Flash Point	290.7±30.7 °C
	Symbol	GHS07, GHS08	Signal Word	Danger

Use of Sulfaquinoxaline

Sulfaquinoxaline is an antimicrobial for veterinary use, with activity against a broad spectrum of Gram-negative and Gram-positive bacteria. Sulfaquinoxaline is used to prevent coccidiosis and bacterial infections[1][2].

Name	Sulfaquinoxaline
Synonym	More Synonyms

Description	Sulfaquinoxaline is an antimicrobial for veterinary use, with activity against a broad spectrum of Gram-negative and Gram-positive bacteria. Sulfaquinoxaline is used to prevent coccidiosis and bacterial infections[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
Target	Bacterial, Parasite[1][2]
In Vivo	Sulfaquinoxaline shows the presence of all antimicrobial residues at concentration higher than the drugs' maximum residue limit (MRL) of 100 μg/kg until two days after discontinuation of the medication[2].
Animal Admin	For the depletion studies, 240 1-day-old Cobb chicks are used. The chickens are housed in pens that contains 30 birds each (10 birds/m2) and are provided ad libitum access to water and non-medicated feed. The chickens are randomly allocated into four experimental groups, labeled from A to D, containing 80 birds each. Chickens in group A form the untreated control group, whereas those in groups B, C and D are treated with 10 mg/kg bw of enrofloxacin, Sulfaquinoxaline or oxytetracycline, respectively, which is administered via drinking water from the 32nd to 34th day of breeding[1].
References	[1]. de Assis DC, et al. Evaluation of the Presence and Levels of Enrofloxacin, Ciprofloxacin, Sulfaquinoxaline and Oxytetracycline in Broiler Chickens after Drug Administration. PLoS One. 2016 Nov 15;11(11):e0166402. [2]. Urbano VR, et al. Influence of pH and ozone dose on sulfaquinoxaline ozonation. J Environ Manage. 2017 Jun 15;195(Pt 2):224-231.

Density	1.5±0.1 g/cm3
Boiling Point	557.0±52.0 °C at 760 mmHg
Melting Point	247-2480C
Molecular Formula	C₁₄H₁₂N₄O₂S
Molecular Weight	300.336
Flash Point	290.7±30.7 °C
Exact Mass	300.068085
PSA	106.35000
LogP	1.58
Vapour Pressure	0.0±1.5 mmHg at 25°C
Index of Refraction	1.718
Storage condition	Refrigerator

Sulfaquinoxaline MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WP2100000

CHEMICAL NAME :: Sulfanilamide, N(sup 1)-2-quinoxalinyl-

CAS REGISTRY NUMBER :: 59-40-5

BEILSTEIN REFERENCE NO. :: 0290026

LAST UPDATED :: 199701

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C14-H12-N4-O2-S

MOLECULAR WEIGHT :: 300.36

WISWESSER LINE NOTATION :: T66 BN ENJ CMSWR DZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1370 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MahWM# Personal Communication from W.M. Mahlburg, Hopkins Agricultural Chemical Co., P.O. Box 7532, Madison, WI 53707, Nov. 16, 1982 Volume(issue)/page/year: 16NOV1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 15 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86 Volume(issue)/page/year: A370,1983 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 9100 mg/kg/26W-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Related to Chronic Data - death

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 82,357,1944

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 1400 mg/kg/14D-I

TOXIC EFFECTS :: Blood - hemorrhage Related to Chronic Data - death

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 82,357,1944 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - A1518 No. of Facilities: 615 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 901 (estimated)

Symbol	GHS07, GHS08
Signal Word	Danger
Hazard Statements	H302-H317-H334
Precautionary Statements	P261-P280-P342 + P311
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes	Xn:Harmful;
Risk Phrases	R22;R42/43
Safety Phrases	S22-S36/37-S45
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	WP2100000
HS Code	2935009090

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HS Code	2935009090
Summary	2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

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A novel, simple and sensitive method was developed for the simultaneous determination of 22 sulfonamides (SAs) in chicken breast muscle by using the dispersive micro-solid-phase extraction (d-μ-SPE) p...

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MFCD00055406

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EINECS 213-526-2

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