DU717

Modify Date: 2024-01-10 16:31:55

DU717 structure	Common Name	DU717
	CAS Number	59943-31-6	Molecular Weight	314.79100
	Density	1.57g/cm3	Boiling Point	483.6ºC at 760 mmHg
	Molecular Formula	C₁₂H₁₅ClN₄O₂S	Melting Point	N/A
	MSDS	N/A	Flash Point	246.3ºC

Use of DU717

DU-717 is an antihypertensive agent.

Name	7-chloro-3-(4-methylpiperazin-1-yl)-4H-1λ6,2,4-benzothiadiazine 1,1-dioxide
Synonym	More Synonyms

Description	DU-717 is an antihypertensive agent.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Cardiovascular Disease
In Vivo	A gas chromatographic method has been developed which enables accurate determination of a new antihypertensive agent, DU-717, in plasma. Accurate determinations are possible over a concentration range from 10 to 150 ng/mL of DU-717 in plasma at a relative standard deviation of 6.2%. The minimum detectable concentration is 1 ng/mL. Plasma levels of DU-717 in spontaneously hypertensive and normotensive rats following single oral administrations (10 mg/kg) have also been determined[1].
Animal Admin	Rats[2] DU-717 (100mg/kg per day, p.o.)-treated SHRSP, SHRSP fed on a HFC diet (including 20% suet, 5% cholesterol and 2% cholic acid) with 1% NaCl in the drinking water, ALR and NAR, 15 rats in each group, are used for EEG recording. Rats, anesthetized with intraperitoneal injection of pentobarbital (30mg/kg), are placed in a stereotaxic frame for exposing the skull, and 6 small pores of 1mm in diameter are made by a dental drill at frontal, parietal, and occipital areas on both sides. Then, stainless steel electrodes (220μ in diameter), insulated except a small loop which is formed at the tip in order to avoid any injury to the dura and the cortex, are inserted through the pores of the skull and settled gently on the dura. Electrodes on both sides are located 2mm apart from mid-sagittal line, and frontal (F), parietal (P), occipital (O) electrodes are located 5mm, 2.5 mm, and 0mm anterior to the interauricular line, respectively. The indifferent electrode (I) is placed on the mid-sagittal line, 4mm anterior to the bregma. All electrodes are connected with insulated copper wires to a miniature receptacle, and the whole assembly is embedded in dental cement. Two weeks after the operation, EEG is repeatedly recorded for several months. When EEG is recorded, rats are in a clear plastic cage (30×40×40cm) and could move freely. EEG is recorded by a ME-920, connected to an autoanalyzer MAF-5, and a photic stimulator is MS-2PS. Monopolar (I-F, I-P, I-O), and bipolar (F-P, P-O, O-F) leading are recorded. EEG is recorded during wakefulness and drowsiness. The recording calibration is 3cm/sec and 100μV/4mm.
References	[1]. Yamaguchi T, et al. Determination of 7-chloro-3-(4-methyl-1-piperazinyl)-4h-1,2,4-benzothiadiazine-1,1-dioxide (DU-717) in plasma using electron-capture gas chromatography. J Chromatogr. 1978 Oct 11;160(1):181-90. [2]. R Horie. rats (ALR) and normotensive atherogenic rats (NAR).

Density	1.57g/cm3
Boiling Point	483.6ºC at 760 mmHg
Molecular Formula	C₁₂H₁₅ClN₄O₂S
Molecular Weight	314.79100
Flash Point	246.3ºC
Exact Mass	314.06000
PSA	73.39000
LogP	1.58780
Index of Refraction	1.712

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DK8187000

CHEMICAL NAME :: 2H-1,2,4-Benzothiadiazine, 7-chloro-3-(4-methyl-1-piperazinyl)-, 1,1-dioxide

CAS REGISTRY NUMBER :: 59943-31-6

LAST UPDATED :: 199310

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C12-H15-Cl-N4-O2-S

MOLECULAR WEIGHT :: 314.82

WISWESSER LINE NOTATION :: T66 BSWN EMJ IG D- AT6N DNTJ D1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - lacrimation Behavioral - tremor Lungs, Thorax, or Respiration - other changes

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 11,294,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Behavioral - tremor Lungs, Thorax, or Respiration - other changes

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 11,294,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 551 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - other changes

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 11,294,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - lacrimation Behavioral - tremor Lungs, Thorax, or Respiration - other changes

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 11,294,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >2412 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Lungs, Thorax, or Respiration - other changes

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 11,294,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 242 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - other changes

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 11,294,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - other changes

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 11,294,1980 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 499 gm/kg/26W-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - proteinuria Endocrine - changes in thymus weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 11,294,1980

2H-1,2,4-BENZOTHIADIAZINE,7-CHLORO-3-(4-METHYL-1-PIPERAZINYL)-,1,1-DIOXIDE

1,1-Dioxyd 3-(4-methylpiperazinyl-1)-7-chlor-2H-1,2,4-benzthiadiazin

7-Chloro-3-(4-methyl-1-piperazinyl)-4H-1,2,4-benzothiadiazine-1,1-dioxide

7-Chloro-3-(4-methyl-1-piperazinyl)-2H-1,2,4-benzothiadiazine-1,1-dioxide

DU 717

DU717

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 2H-1,2,4-Benzothiadiazine,7-chloro-3-(4-methyl-1-piperazinyl)-, 1,1-dioxide
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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Price: $480/1mg

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DU717

Use of DU717

Names

DU717 Biological Activity

Chemical & Physical Properties

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

Synonyms