hCAIX/XII-IN-8

Modify Date: 2024-01-10 17:08:42

hCAIX/XII-IN-8 structure	Common Name	hCAIX/XII-IN-8
	CAS Number	59994-64-8	Molecular Weight	426.28
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₆H₁₃Cl₂N₅O₃S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of hCAIX/XII-IN-8

hCAIX/XII-IN-8 (compound 3g) is a potent human (carbonic anhydrase) CA IX and XII inhibitor, with Ki values of 8.5 and 6.7 nM, respectively. hCAIX/XII-IN-8 shows particularly strong inhibitory activity against the tumor-associated membrane-bound isoforms, hCA IX and XII, while maintaining a high selectivity ratio over cytosolic off-target isoforms hCA I and II[1].

Name	hCAIX/XII-IN-8

Description	hCAIX/XII-IN-8 (compound 3g) is a potent human (carbonic anhydrase) CA IX and XII inhibitor, with Ki values of 8.5 and 6.7 nM, respectively. hCAIX/XII-IN-8 shows particularly strong inhibitory activity against the tumor-associated membrane-bound isoforms, hCA IX and XII, while maintaining a high selectivity ratio over cytosolic off-target isoforms hCA I and II[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Carbonic Anhydrase
Target	hCA XII:6.7 nM (Ki) hCA IX:8.5 nM (Ki) hCA II:72.0 nM (Ki) hCA I:5269 nM (Ki)
References	[1]. Akocak S, et al. Potent and selective carbonic anhydrase inhibition activities of pyrazolones bearing benzenesulfonamides. Bioorg Med Chem Lett. 2023 Oct 15;95:129479.

Molecular Formula	C₁₆H₁₃Cl₂N₅O₃S
Molecular Weight	426.28

hCAIX/XII-IN-8

Use of hCAIX/XII-IN-8

Names

hCAIX/XII-IN-8 Biological Activity

Chemical & Physical Properties