Tyramine

Modify Date: 2024-01-02 20:50:50

Tyramine Structure
Tyramine structure
Common Name Tyramine
CAS Number 60-19-5 Molecular Weight 137.179
Density 1.1±0.1 g/cm3 Boiling Point 325.2±0.0 °C at 760 mmHg
Molecular Formula C8H12ClNO Melting Point 253-255 °C(lit.)
MSDS Chinese USA Flash Point 119.2±20.4 °C

 Use of Tyramine


Tyramine hydrochloride is an amino acid that helps regulate blood pressure. Tyramine hydrochloride occurs naturally in the body, and it's found in certain foods[1].

 Names

Name Tyramine hydrochloride
Synonym More Synonyms

 Tyramine Biological Activity

Description Tyramine hydrochloride is an amino acid that helps regulate blood pressure. Tyramine hydrochloride occurs naturally in the body, and it's found in certain foods[1].
Related Catalog
Target

Human Endogenous Metabolite

In Vitro Tyramine is normally broken down in your body by an enzyme called MAO (monoamine oxidase)[1].
References

[1]. C Brown , et al. The Monoamine Oxidase Inhibitor-Tyramine Interaction. J Clin Pharmacol. 1989 Jun;29(6):529-32.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 325.2±0.0 °C at 760 mmHg
Melting Point 253-255 °C(lit.)
Molecular Formula C8H12ClNO
Molecular Weight 137.179
Flash Point 119.2±20.4 °C
Exact Mass 137.084061
PSA 46.25000
LogP 0.72
Vapour Pressure 0.0±0.7 mmHg at 25°C
Index of Refraction 1.577
Storage condition Store at RT.

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SJ6050000
CHEMICAL NAME :
Phenol, p-(2-aminoethyl)-, monohydrochloride
CAS REGISTRY NUMBER :
60-19-5
LAST UPDATED :
199709
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C8-H11-N-O.Cl-H
MOLECULAR WEIGHT :
173.66
WISWESSER LINE NOTATION :
Z2R DQ &G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
710 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
208 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - other changes
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2750 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
1044 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - tremor Behavioral - convulsions or effect on seizure threshold

MUTATION DATA

TYPE OF TEST :
Mutation in mammalian somatic cells
TEST SYSTEM :
Rodent - mouse Lymphocyte
DOSE/DURATION :
2530 umol/L
REFERENCE :
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year: 3,193,1988

 Safety Information

Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases S22-S24/25-S36-S26
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS NL4375000
HS Code 29222900

 Synthetic Route

 Customs

HS Code 2922299090
Summary 2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Articles15

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 Synonyms

p-b-Aminoethylphenol
P-hydroxy-b-phenylethylamine
Z2R DQ
MFCD00012682
4-Hydroxy phenylethylamine
EINECS 206-446-4
4-hydroxy-Benzeneethanamine
Phenol, p- (2-aminoethyl)-
4-Hydroxy-β-phenylethylamine
4- (2-aminoethyl)-Phenol
p-(2-aminoethyl)-Phenol
α-(4-Hydroxyphenyl)-β-aminoethane
β-(4-Hydroxyphenyl)ethylamine
2-p-Hydroxyphenylethylamine
a-(4-Hydroxyphenyl)-b-aminoethane
p-β-Aminoethylphenol
4-hydroxy-phenethylamine
p-Hydroxy-β-phenethylamine
4-(2-Aminoethyl)phenol
4-(2-aminoethyl)phenol,hydrochloride
b-(4-Hydroxyphenyl)ethylamine
Phenol, 4-(2-aminoethyl)-
P-hydroxy-β-phenylethylamine
Tyramine base
P-hydroxy-b-phenethylamine
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