Yuanhuacine

Modify Date: 2024-01-09 16:27:24

Yuanhuacine structure	Common Name	Yuanhuacine
	CAS Number	60195-70-2	Molecular Weight	648.73900
	Density	1.35g/cm3	Boiling Point	765.9ºC at 760 mmHg
	Molecular Formula	C₃₇H₄₄O₁₀	Melting Point	N/A
	MSDS	N/A	Flash Point	236.9ºC

Use of Yuanhuacine

Yuanhuacine (Gnidilatidin), a daphnane diterpenoid from the flowers of Daphne genkwa with extensive anti-tumor activity. Yuanhuacine is a DNA-damaging agent with orally active[1][2].

Name	Yuanhuacine
Synonym	More Synonyms

Description	Yuanhuacine (Gnidilatidin), a daphnane diterpenoid from the flowers of Daphne genkwa with extensive anti-tumor activity. Yuanhuacine is a DNA-damaging agent with orally active[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
References	[1]. Ji In Kang, et al. Anti-Tumor Activity of Yuanhuacine by Regulating AMPK/mTOR Signaling Pathway and Actin Cytoskeleton Organization in Non-Small Cell Lung Cancer Cells. PLoS One. 2015 Dec 11;10(12):e0144368. [2]. Ruowen Zhang, et al. The Chinese herb isolate yuanhuacine (YHL-14) induces G2/M arrest in human cancer cells by up-regulating p21 protein expression through an p53 protein-independent cascade. J Biol Chem. 2014 Mar 7;289(10):6394-403.

Description

Yuanhuacine (Gnidilatidin), a daphnane diterpenoid from the flowers of Daphne genkwa with extensive anti-tumor activity. Yuanhuacine is a DNA-damaging agent with orally active[1][2].

Related Catalog

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

References

[1]. Ji In Kang, et al. Anti-Tumor Activity of Yuanhuacine by Regulating AMPK/mTOR Signaling Pathway and Actin Cytoskeleton Organization in Non-Small Cell Lung Cancer Cells. PLoS One. 2015 Dec 11;10(12):e0144368.

[2]. Ruowen Zhang, et al. The Chinese herb isolate yuanhuacine (YHL-14) induces G2/M arrest in human cancer cells by up-regulating p21 protein expression through an p53 protein-independent cascade. J Biol Chem. 2014 Mar 7;289(10):6394-403.

Density	1.35g/cm3
Boiling Point	765.9ºC at 760 mmHg
Molecular Formula	C₃₇H₄₄O₁₀
Molecular Weight	648.73900
Flash Point	236.9ºC
Exact Mass	648.29300
PSA	144.28000
LogP	3.70440
Index of Refraction	1.633
Storage condition	2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VW7800000

CHEMICAL NAME :: Simplexin, 12-(benzoyloxy)-22,23,24,25-tetradehydro-, (12-beta,22E,24E)-

CAS REGISTRY NUMBER :: 60195-70-2

LAST UPDATED :: 199009

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C37-H44-O10

MOLECULAR WEIGHT :: 648.81

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1700 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Rodent - mouse Leukocyte

DOSE/DURATION :: 8400 nmol/L

REFERENCE :: EJCODS European Journal of Cancer and Clinical Oncology. (Pergamon Press, c/o Elsevier Science, 660 White Plains Rd., Tarrytown, NY 10591) V.17(7)- 25, 1981-89. For publisher information, see EJCAEL Volume(issue)/page/year: 22,45,1986

12-O-Benzoyl-14...

CAS#:83847-79-4

Yuanhuacine

CAS#:60195-70-2

Literature: Ohigashi; Hirota; Ohtsuka; et al. Agricultural and Biological Chemistry, 1982 , vol. 46, # 10 p. 2605 - 2608

Precursor 1
CAS#:83847-79-4 12-O-Benzoyl-14...
DownStream 0

Odoracin

From gnidia

gnidilatidin

Stillingia factor S6,gnidilatidin

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Yuanhuacine
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Purity: 98.0%
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Price: ￥3400/1 mg

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Yuanhuacine

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CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

Synthetic Route

Precursor & DownStream

Synonyms