Dansyl chloride

Modify Date: 2024-01-02 20:33:03

Dansyl chloride Structure
Dansyl chloride structure
Common Name Dansyl chloride
CAS Number 605-65-2 Molecular Weight 269.747
Density 1.4±0.1 g/cm3 Boiling Point 371.3±22.0 °C at 760 mmHg
Molecular Formula C12H12ClNO2S Melting Point 72-74 °C(lit.)
MSDS Chinese USA Flash Point 178.4±22.3 °C
Symbol GHS05
GHS05
Signal Word Danger

 Use of Dansyl chloride


Dansyl chloride is a reagent that reacts with primary amino groups in both aliphatic and aromatic amines to produce stable blue- or blue-green-fluorescent sulfonamide adducts. Dansyl chloride is widely used to modify amino acids; specifically, protein sequencing and amino acid analysis. It can also be used to label hydroxyl and carboxylic acid functional groups.

 Names

Name dansyl chloride
Synonym More Synonyms

 Dansyl chloride Biological Activity

Description Dansyl chloride is a reagent that reacts with primary amino groups in both aliphatic and aromatic amines to produce stable blue- or blue-green-fluorescent sulfonamide adducts. Dansyl chloride is widely used to modify amino acids; specifically, protein sequencing and amino acid analysis. It can also be used to label hydroxyl and carboxylic acid functional groups.
Related Catalog

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 371.3±22.0 °C at 760 mmHg
Melting Point 72-74 °C(lit.)
Molecular Formula C12H12ClNO2S
Molecular Weight 269.747
Flash Point 178.4±22.3 °C
Exact Mass 269.027740
PSA 45.76000
LogP 3.67
Vapour Pressure 0.0±0.8 mmHg at 25°C
Index of Refraction 1.636
Storage condition 2-8°C
Water Solubility acetone: 50 mg/mL

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
QK3688000
CHEMICAL NAME :
1-Naphthalenesulfonyl chloride, 5-(dimethylamino)-
CAS REGISTRY NUMBER :
605-65-2
BEILSTEIN REFERENCE NO. :
2217205
LAST UPDATED :
199701
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C12-H12-Cl-N-O2-S
MOLECULAR WEIGHT :
269.76
WISWESSER LINE NOTATION :
L66J BSWG GN1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
56 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#00262

 Safety Information

Symbol GHS05
GHS05
Signal Word Danger
Hazard Statements H314
Precautionary Statements P280-P305 + P351 + P338-P310
Personal Protective Equipment Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes C:Corrosive;
Risk Phrases R34
Safety Phrases S26-S36/37/39-S45
RIDADR UN 3261 8/PG 2
WGK Germany 3
RTECS QK3688000
Packaging Group III
Hazard Class 8
HS Code 29214980

 Customs

HS Code 2921199090
Summary 2921199090 other acyclic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

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 Synonyms

5-(Dimethylamino)naphthalene-1-sulfonyl chloride
EINECS 210-092-6
5-(Dimethylamino)-1-naphthalenesulfonyl chloride
MFCD00003985
1-chlorosulfonyl-5-(dimethylamino)naphthalene
Dansyl chloride
1-Naphthalenesulfonyl chloride, 5-(dimethylamino)-
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