MK-0773

Modify Date: 2024-01-02 19:35:17

MK-0773 Structure
MK-0773 structure
Common Name MK-0773
CAS Number 606101-58-0 Molecular Weight 479.590
Density 1.3±0.1 g/cm3 Boiling Point 754.2±60.0 °C at 760 mmHg
Molecular Formula C27H34FN5O2 Melting Point N/A
MSDS N/A Flash Point 409.9±32.9 °C

 Use of MK-0773


MK-0773 is a selective androgen receptor modulators (SARMs) that binds to AR with an IC50 of 6.6 nM.

 Names

Name (1S,3aS,3bS,5aR,9aS,9bS,11aS)-8-fluoro-N-(1H-imidazo[4,5-b]pyridin-2-ylmethyl)-6,9a,11a-trimethyl-7-oxo-2,3,3a,3b,4,5,5a,9b,10,11-decahydro-1H-indeno[5,4-f]quinoline-1-carboxamide
Synonym More Synonyms

 MK-0773 Biological Activity

Description MK-0773 is a selective androgen receptor modulators (SARMs) that binds to AR with an IC50 of 6.6 nM.
Related Catalog
Target

IC50: 6.6 nM (AR)

In Vitro The IC50 of MK-0773 binding to AR is increased 3.5-fold in the presence of 25% rat serum and 13-fold in the presence of 25% human serum, indicating that it binds to serum proteins. The affinity of MK-0773 for AR across species is evaluated using COS cells transfected with AR, and IC50 values are very similar in four species (rat, 0.50 nM; dog, 0.55 nM; rhesus, 0.45 nM; human, 0.65 nM)[1].
In Vivo MK-0773 (6 and 80 mg/kg, s.c.) produces exposure-related stimulatory effects on cortical BFR and LBM in the OVX rat model. MK-0773 (5, 15, and 80 mg/kg, s.c.) increases seminal vesicle weights, and has reduced effects on the prostate. The partial agonism and tissue selectivity of MK-0773 does not translate into differential effects on lipid metabolism in OVX rats[1].
Animal Admin Rats: Prostate and seminal vesicles are studied in 3-4-month-old 250-300-g rats after orchidectomy (ORX). Nine days after surgery, animals are injected (subcutaneously) daily with test compounds for 17 days, and the weight of the seminal vesicles (SVs) is compared with ORX rats treated with vehicle or DHT as a positive control.
References

[1]. Schmidt A, et al. Discovery of the selective androgen receptor modulator MK-0773 using a rational development strategy based on differential transcriptional requirements for androgenic anabolism versus reproductive physiology. J Biol Chem. 2010 May 28;285

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 754.2±60.0 °C at 760 mmHg
Molecular Formula C27H34FN5O2
Molecular Weight 479.590
Flash Point 409.9±32.9 °C
Exact Mass 479.269653
PSA 94.47000
LogP 3.17
Vapour Pressure 0.0±2.5 mmHg at 25°C
Index of Refraction 1.632
Storage condition 2-8℃

 Synonyms

mk 0773
(4aS,4bS,6aS,7S,9aS,9bS,11aR)-3-Fluoro-N-(1H-imidazo[4,5-b]pyridin-2-ylmethyl)-1,4a,6a-trimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxamide
1H-Indeno[5,4-f]quinoline-7-carboxamide, 3-fluoro-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-N-(1H-imidazo[4,5-b]pyridin-2-ylmethyl)-1,4a,6a-trimethyl-2-oxo-, (4aS,4bS,6aS,7S,9aS,9bS,11aR)-
unii-5730vnw22x
MK-0773
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