Conduritol B Epoxide (Conduritol Epoxide)

Modify Date: 2024-01-06 17:33:48

Conduritol B Epoxide (Conduritol Epoxide) structure	Common Name	Conduritol B Epoxide (Conduritol Epoxide)
	CAS Number	6090-95-5	Molecular Weight	162.141
	Density	1.9±0.1 g/cm3	Boiling Point	360.5±42.0 °C at 760 mmHg
	Molecular Formula	C₆H₁₀O₅	Melting Point	157-159ºC
	MSDS	USA	Flash Point	171.8±27.9 °C

Use of Conduritol B Epoxide (Conduritol Epoxide)

Conduritol B epoxide is an irreversible covalently bound acid β-glucosidase (GCase) inhibitor, with IC50s of 1 and 100 μM for β-glucosidase and α-glucosidase respectively.

Name	Conduritol B Epoxide
Synonym	More Synonyms

Description	Conduritol B epoxide is an irreversible covalently bound acid β-glucosidase (GCase) inhibitor, with IC50s of 1 and 100 μM for β-glucosidase and α-glucosidase respectively.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
Target	IC50: 1 μM (β-glucosidase), 100 μM (α-glucosidase)
In Vitro	Treating N2a and Conduritol B epoxide-N2a cells with G6 gave GC reductions to 7% and 26% of untreated levels, respectively. G6 treated Conduritol B epoxide-N2a also has significantly decreased GS. Co-treatment of G6 and dantrolene of Conduritol B epoxide-N2a cells lead to a similar degree of GC and GS reduction as G6 alone, indicating a specific effect of G6 on inhibition of substrate accumulation, Conduritol B epoxide-N2a cells have higher calcium levels than in N2a cells without caffeine at baseline. Conduritol B epoxide-N2a cells show a significant increase in cytosolic calcium levels compared to N2a cells. Conduritol B epoxide-N2a cells show a significant reduction in OCR as evidenced by approximately 50% in all the parameters, including rate of ATP production, basal respiration, and maximal respiration, compared to N2a cells, indicating reduced mitochondrial function in this nGD cell model. In dantrolene-treated Conduritol B epoxide-N2a cells, levels of Ryr3 are increased to 76% of WT level[1].
In Vivo	Conduritol B epoxide treatment of 4L, 9H, 9V and WT mice (100 mg/kg/day, i.p.) from postnatal day 5 to 11 does not induce α-synuclein aggregates. Long-term daily Conduritol B epoxide treatment of 4L mice (100 mg/kg/day of Conduritol B epoxide from postnatal day 15 for 24 or 36 doses) leads to hind limb paralysis and small amounts of α-synuclein accumulation in the olfactory bulb, brainstem, and PVP near D3V (dorsal 3rd ventricle)[2].
Kinase Assay	Cells are homogenized in 1% sodium taurocholate/1% Triton X-100. GCase activity is determined fluorometrically using 4MU-Glucose as the substrate in 0.25% sodium taurocholate, 0.25% Triton X-100 and 0.1M citric-phosphate buffer (pH 5.6). Brain tissues are homogenized in 1X PBS and incubated in 5 µM brain phosphatidylserine and 0.1M citric-phosphate buffer (pH 5.6) for GCase activity assay using 4MU-Glucose as substrate. Protein concentrations are determined by BCA assay using BSA as standard.
Animal Admin	Gba1 point mutated 4L, 9H and 9V mice or WT mice are intraperitoneally injected with 100 mg/kg/day of Conduritol B epoxide. In short-term experiments, daily injections are initiated at postnatal day 5 and continued for 6 daily doses. The mice are sacrificed on day 12 or 2 months after last injection. In long-term experiments, 4L mice are injected daily beginning at postnatal day 15 for 24 or 36 daily doses and sacrificed the day after last injection. Mice are perfused with PBS and organs are harvested for enzyme activity, lipid and histological analyses.
References	[1]. Liou B, et al. Modulating ryanodine receptors with dantrolene attenuates neuronopathic phenotype in Gaucher disease mice. Hum Mol Genet. 2016 Sep 20. pii: ddw322. [Epub ahead of print] [2]. YH Xu, et al. Accumulation and distribution of α-synuclein and ubiquitin in the CNS of Gaucher disease mouse models. Mol Genet Metab. Author manuscript; available in PMC 2012 Apr 1.

Density	1.9±0.1 g/cm3
Boiling Point	360.5±42.0 °C at 760 mmHg
Melting Point	157-159ºC
Molecular Formula	C₆H₁₀O₅
Molecular Weight	162.141
Flash Point	171.8±27.9 °C
Exact Mass	162.052826
PSA	93.45000
LogP	-0.49
Vapour Pressure	0.0±1.8 mmHg at 25°C
Index of Refraction	1.732
Storage condition	2-8℃

Precursor 8
CAS#:110550-28-2 (+)-(1S,2R,3S,4... CAS#:138258-55-6 (+/-) conduritol B CAS#:4381-96-8 (+/-)-(1,3/2,4)... CAS#:40617-60-5 D-chiro-Inosito...
CAS#:120710-66-9 (±)-1,6-di-O-be... CAS#:120679-73-4 (+/-)-3,4-di-O-... CAS#:85798-11-4 (4S,5R,6S)-4,5,... CAS#:102997-58-0 conduritol B
DownStream 0

Conduritol B epoxide

UNII:NHM754Q310

7-Oxabicyclo[4.1.0]heptane-2,3,4,5-tetrol, (1R,2R,3S,4S,5R,6S)-

(1R,2R,3S,4S,5R,6S)-7-Oxabicyclo[4.1.0]heptane-2,3,4,5-tetrol

CBE

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Conduritol B Epoxide (Conduritol Epoxide)
Price: Click To Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Conduritol B Epoxide (Conduritol Epoxide)
Price: ￥1836.0/25mg ￥3366.0/50mg ￥566.0/5mg ￥896.0/10mg
Purity: 97.0%
Delivery: 1 Day
Contact: Liu jia
Email: 2130147988@qq.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: Conduritol B Epoxide（CBE）
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

DC Chemicals Limited
China
Product Name: myo-Inositol,1,2-anhydro-
Price: $600.0/100mg $1200.0/250mg $2300.0/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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Price: $66/10mM*1mLinWater

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