Geraniin

Modify Date: 2024-01-02 18:33:37

Geraniin Structure
Geraniin structure
 Common Name Geraniin
CAS Number 60976-49-0 Molecular Weight 952.645
Density 2.3±0.1 g/cm3 Boiling Point N/A
Molecular Formula C41H28O27 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Geraniin


Geraniin is a TNF-α releasing inhibitor with numerous activities including anticancer, anti-inflammatory, and anti-hyperglycemic activities, with an IC50 of 43 μM.

 Names

Name b-D-Glucopyranose
Synonym More Synonyms

 Geraniin Biological Activity

Description Geraniin is a TNF-α releasing inhibitor with numerous activities including anticancer, anti-inflammatory, and anti-hyperglycemic activities, with an IC50 of 43 μM.
Related Catalog
Target

IC50: 43 μM (TNF-α)[1].

In Vitro The IC50 value of TNF-α release inhibition is 43 μM for Geraniin[1]. Geraniin has long been used as a medicinal herb and possesses numerous activities including anticancer, anti-inflammatory, and anti-hyperglycemic activities. Geraniin significantly decreases the viability of OVCAR3 and SKOV3 cells in a concentration-dependent fashion. The IC50 value for Geraniin treatment is 34.5±2.8 μM in OVCAR3 cells and 23.6±1.9 μM in SKOV3 cells. However, Geraniin up to the maximal concentration used (80 μM) has no significant impact on the viability of normal human ovarian surface epithelial cells. Treatment with 10 and 40 μM of Geraniin for 48 h causes a significant increase in apoptosis (16.8±1.2% and 22.6±1.4%, respectively), compared with control OVCAR3 cells (3.9±1.1%). Similar results are observed in SKOV3 cells[2].
In Vivo Treatment with Geraniin prior to application of okadaic acid delays development of tumors compared with control group, reduces the percentage of tumor bearing mice from 80.0% to 40.0%, and reduces the average numbers of tumor per mouse from 3.8 to 1.1 in week 20. It is also showed that oral administration of Geraniin to rats (50 mg/kg/d or 100 mg/kg/d) inhibit the elevation of serum total cholesterol, lipid peroxide, free fatty acid, triglyceride, glutamic oxaloacetic transaminase and glutamic pyruvic transaminase induced by treatment with peroxidized oil[1].
Cell Assay Human ovarian cancer cell lines OVCAR3 and SKOV3 are used. Cells are exposed to different concentrations (5, 10, 20, 40, and 80 μM) of Geraniin for 48 h and examined for viability, apoptosis, and gene expression. The concentration range is selected based on previous studies[2].
References

[1]. Okabe S, et al. New TNF-alpha releasing inhibitors, geraniin and corilagin, in leaves of Acer nikoense, Megusurino-ki. Biol Pharm Bull. 2001 Oct;24(10):1145-8.

[2]. Wang X, et al. Geraniin suppresses ovarian cancer growth through inhibition of NF-κB activation and downregulation of Mcl-1 expression. J Biochem Mol Toxicol. 2017 Sep;31(9).

 Chemical & Physical Properties

Density 2.3±0.1 g/cm3
Molecular Formula C41H28O27
Molecular Weight 952.645
Exact Mass 952.081787
PSA 450.25000
LogP 3.41
Index of Refraction 1.948

 Safety Information

HS Code 2932999099

 Synthetic Route

Elaeocarpusin structure

Elaeocarpusin

CAS#:102382-31-0

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ac1l4jhe structure

ac1l4jhe

CAS#:81905-83-1

Geraniin Structure

Geraniin

CAS#:60976-49-0

Literature: Chemical and Pharmaceutical Bulletin, , vol. 34, # 10 p. 4075 - 4082
Elaeocarpusin structure

Elaeocarpusin

CAS#:102382-31-0

~%

Geraniin Structure

Geraniin

CAS#:60976-49-0

ac1l4jhe structure

ac1l4jhe

CAS#:81905-83-1

Literature: Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 369 - 376

 Customs

HS Code 2932999099
Summary 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

b-d-glucopyranose
Benzoic acid, 3,4,5-trihydroxy-, (3R,4aR,11R,11aS,25R,25aR,29S)-2,3,4,4a,9,11a,13,22,24,25,25a,27-dodecahydro-3,4,4,6,7,15,16,17,18,19,20-undecahydroxy-2,9,13,22,27-pentaoxo-3,5-epoxy-25,11-(epoxymethano)-11H-dibenzo[h,j]dibenzo[7,8:9,10][1,5]dioxacycloundecino[3,2-b][1,6]dioxacyclododecin-29-yl ester
Geraniin
(1R,7R,8S,26R,28S,29R,38R)-1,13,14,15,18,19,20,34,35,39,39-Undecahydroxy-2,5,10,23,31-pentaoxo-6,9,24,27,30,40-hexaoxaoctacyclo[34.3.1.0.0.0.0.0.0]tetraconta-3,1 ; 1,13,15,17,19,21,32,34,36-decaen-28-yl 3,4,5-trihydroxybenzoate
(1R,7R,8S,26R,28S,29R,38R)-1,13,14,15,18,19,20,34,35,39,39-Undecahydroxy-2,5,10,23,31-pentaoxo-6,9,24,27,30,40-hexaoxaoctacyclo[34.3.1.0.0.0.0.0.0]tetraconta-3,11,13,15,17,19,21,32,34,36-decaen-28-yl 3,4,5-trihydroxybenzoate
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