Tenuazonic acid-(Copper salt)

Modify Date: 2024-01-04 12:44:39

Tenuazonic acid-(Copper salt) Structure
Tenuazonic acid-(Copper salt) structure
Common Name Tenuazonic acid-(Copper salt)
CAS Number 610-88-8 Molecular Weight 197.231
Density 1.2±0.1 g/cm3 Boiling Point 401.1±45.0 °C at 760 mmHg
Molecular Formula C10H15NO3 Melting Point 74.5°C
MSDS Chinese USA Flash Point 196.4±28.7 °C
Symbol GHS06
GHS06
Signal Word Danger

 Use of Tenuazonic acid-(Copper salt)


Tenuazonic acid, belonging to tetramic acids that are the largest family of natural products, is a putative nonhost-selective mycotoxin isolated from Alternaria alternate[1]. Tenuazonic acid blocks electron transport beyond primary quinone acceptor (QA) by interacting with D1 protein and it is a broad-spectrum and effective photosystem II (PSII) inhibitor[2].

 Names

Name Tenuazonic Acid
Synonym More Synonyms

 Tenuazonic acid-(Copper salt) Biological Activity

Description Tenuazonic acid, belonging to tetramic acids that are the largest family of natural products, is a putative nonhost-selective mycotoxin isolated from Alternaria alternate[1]. Tenuazonic acid blocks electron transport beyond primary quinone acceptor (QA) by interacting with D1 protein and it is a broad-spectrum and effective photosystem II (PSII) inhibitor[2].
Related Catalog
Target

PSII[2]

References

[1]. Zhou B, et al. An evaluation of tenuazonic acid, a potential biobased herbicide in cotton. Pest Manag Sci. 2019 Mar 7.

[2]. Chen S, et al. Recent advances in tenuazonic acid as a potential herbicide. Pestic Biochem Physiol. 2017 Nov;143:252-257.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 401.1±45.0 °C at 760 mmHg
Melting Point 74.5°C
Molecular Formula C10H15NO3
Molecular Weight 197.231
Flash Point 196.4±28.7 °C
Exact Mass 197.105194
PSA 66.40000
LogP 0.81
Vapour Pressure 0.0±2.1 mmHg at 25°C
Index of Refraction 1.519
Storage condition -20°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UY7425000
CHEMICAL NAME :
3-Pyrrolin-2-one, 3-acetyl-5-sec-butyl-4-hydroxy-, L-
CAS REGISTRY NUMBER :
610-88-8
LAST UPDATED :
199709
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C10-H15-N-O3
MOLECULAR WEIGHT :
197.26
WISWESSER LINE NOTATION :
T5MV EHJ CV1 DQ EY2&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
225 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 5,65,1981
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
81 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 4,87,1973
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
145 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 5,65,1981
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
125 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 5,65,1981

 Safety Information

Symbol GHS06
GHS06
Signal Word Danger
Hazard Statements H301
Precautionary Statements P301 + P310
Hazard Codes Xn
Risk Phrases 22
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
RTECS UY7425000
Packaging Group III
Hazard Class 6.1(b)
HS Code 2933990090

 Synthetic Route

~%

Tenuazonic acid-(Copper salt) Structure

Tenuazonic acid...

CAS#:610-88-8

Literature: Matsuo; Kitaguchi; Takata; Tanaka Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 8 p. 2494 - 2502

~%

Tenuazonic acid-(Copper salt) Structure

Tenuazonic acid...

CAS#:610-88-8

Literature: Poncet, Joel; Jouin, Patrick; Castro, Bertrand; Nicolas, Louisette; Boutar, Mohamed; Gaudemer, Alain Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , p. 611 - 616

~%

Tenuazonic acid-(Copper salt) Structure

Tenuazonic acid...

CAS#:610-88-8

Literature: Poncet, Joel; Jouin, Patrick; Castro, Bertrand; Nicolas, Louisette; Boutar, Mohamed; Gaudemer, Alain Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , p. 611 - 616

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles28

More Articles
Natural occurrence of four Alternaria mycotoxins in tomato- and citrus-based foods in China.

J. Agric. Food Chem. 63(1) , 343-8, (2015)

A total of 70 tomato-based and 86 citrus-based products collected in China were analyzed for alternariol, alternariol monomethyl ether, tentoxin, and tenuazonic acid by ultraperformance liquid chromat...

Evaluation of analogs of reutericyclin as prospective candidates for treatment of staphylococcal skin infections.

Antimicrob. Agents Chemother. 53 , 4028-31, (2009)

The potential for reutericyclin derivatives to be used as topical antibiotics to treat staphylococcal skin infections was investigated. All reutericyclins inhibited the growth of clinical isolates of ...

Effects of nisin and reutericyclin on resistance of endospores of Clostridium spp. to heat and high pressure.

Food Microbiol. 34(1) , 46-51, (2013)

The effects of high pressure, temperature, and antimicrobial compounds on endospores of Clostridium spp. were examined. Minimal inhibitory concentrations (MIC) of nisin and reutericyclin were determin...

 Synonyms

3-acetyl-5-(butan-2-yl)-4-hydroxy-1,5-dihydro-2H-pyrrol-2-one
3-Acetyl-5-sec-butyl-4-hydroxy-1,5-dihydro-2H-pyrrol-2-one
4-acetyl-2-butan-2-yl-3-hydroxy-1,2-dihydropyrrol-5-one
2H-Pyrrol-2-one, 3-acetyl-1,5-dihydro-4-hydroxy-5-(1-methylpropyl)-