Clavulanate lithium

Modify Date: 2024-01-02 09:09:57

Clavulanate lithium Structure
Clavulanate lithium structure
Common Name Clavulanate lithium
CAS Number 61177-44-4 Molecular Weight 205.09400
Density N/A Boiling Point N/A
Molecular Formula C8H8LiNO5 Melting Point N/A
MSDS N/A Flash Point N/A
Symbol GHS08
GHS08
Signal Word Danger

 Use of Clavulanate lithium


Clavulanate lithium is a potent β-lactamase inhibitor and acts as an antibiotic[1][2].

 Names

Name lithium clavulanate
Synonym More Synonyms

 Clavulanate lithium Biological Activity

Description Clavulanate lithium is a potent β-lactamase inhibitor and acts as an antibiotic[1][2].
Related Catalog
Target

β-lactamase[1]

In Vitro Clavulanate lithium has weak antibacterial activity against most organisms when administered alone, but given in combination with beta-lactam antibiotics prevents antibiotic inactivation by microbial lactamase[1]. Clavulanate lithium (0.25, 0.5 mg/L) causes a relatively slow inhibition of growth, and a higher concentration (1 mg/L) is only marginally more effective than 0.5 mg/L [2]. Cell Viability Assay[2] Cell Line: L. pneumophila NCTC 1119 Concentration: 0.25 mg/L, 0.5 mg/L, 1 mg/L Incubation Time: 0-35 hours Result: Caused a relatively slow inhibition of growth.
References

[1]. Reading C, et al. Clavulanic Acid: a Beta-Lactamase-Inhibiting Beta-Lactam from Streptomyces clavuligerus. Antimicrob Agents Chemother. 1977 May; 11(5): 852–857.

[2]. Stokes DH, et al. Bactericidal effects of amoxycillin/clavulanic acid against intracellular Legionella pneumophila in tissue culture studies. J Antimicrob Chemother. 1989 Apr;23(4):547-56.

 Chemical & Physical Properties

Molecular Formula C8H8LiNO5
Molecular Weight 205.09400
Exact Mass 205.05600
PSA 89.90000

 Safety Information

Symbol GHS08
GHS08
Signal Word Danger
Hazard Statements H360
Precautionary Statements P201-P280-P308 + P313
Hazard Codes Xn
RIDADR NONH for all modes of transport
HS Code 2934999090

 Customs

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

CLAVULANIC ACID LITHIUM SALT
Clavulanate Lithium
CLAVULANATE LITHIUM SALT, ANTIBIOTIC FOR CULTURE MEDIA USE ONLY
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