5-Phenyl-1,2,5-thiadiazolidin-3-one 1,1-dioxide

Modify Date: 2024-01-11 06:17:05

5-Phenyl-1,2,5-thiadiazolidin-3-one 1,1-dioxide structure	Common Name	5-Phenyl-1,2,5-thiadiazolidin-3-one 1,1-dioxide
	CAS Number	612530-44-6	Molecular Weight	212.22600
	Density	1.483	Boiling Point	N/A
	Molecular Formula	C₈H₈N₂O₃S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of 5-Phenyl-1,2,5-thiadiazolidin-3-one 1,1-dioxide

PTP1B-IN-1 is a potent protein tyrosine phosphatase-1B (PTP1B) inhibitor with IC50 of 1.6 mM; 1,2,5-thiadiazolidin-3-one-1,1-dioxide scaffold for derivatives synthesis.

Name	5-Phenyl-1,2,5-thiadiazolidin-3-one 1,1-dioxide
Synonym	More Synonyms

Description	PTP1B-IN-1 is a potent protein tyrosine phosphatase-1B (PTP1B) inhibitor with IC50 of 1.6 mM; 1,2,5-thiadiazolidin-3-one-1,1-dioxide scaffold for derivatives synthesis.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase Research Areas >> Metabolic Disease
References	[1]. Black E, et al. Structure-based design of protein tyrosine phosphatase-1B inhibitors. Bioorg Med Chem Lett. 2005 May 16;15(10):2503-7. [2]. Vintonyak VV, et al. Using small molecules to target protein phosphatases. Bioorg Med Chem. 2011 Apr 1;19(7):2145-55.

Description

PTP1B-IN-1 is a potent protein tyrosine phosphatase-1B (PTP1B) inhibitor with IC50 of 1.6 mM; 1,2,5-thiadiazolidin-3-one-1,1-dioxide scaffold for derivatives synthesis.

Related Catalog

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase

Research Areas >> Metabolic Disease

References

[1]. Black E, et al. Structure-based design of protein tyrosine phosphatase-1B inhibitors. Bioorg Med Chem Lett. 2005 May 16;15(10):2503-7.

[2]. Vintonyak VV, et al. Using small molecules to target protein phosphatases. Bioorg Med Chem. 2011 Apr 1;19(7):2145-55.