D-Saccharic acid 1,4-lactone hydrate structure
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Common Name | D-Saccharic acid 1,4-lactone hydrate | ||
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CAS Number | 61278-30-6 | Molecular Weight | 192.12400 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C6H10O8 | Melting Point | 80-82ºC | |
MSDS | Chinese USA | Flash Point | N/A |
Use of D-Saccharic acid 1,4-lactone hydrateD-Saccharic acid 1,4-lactone hydrate is a potent β-glucuronidase inhibitor (IC50=48.4 μM). D-Saccharic acid 1,4-lactone hydrate can be used as a standard drug compared with novel β-glucuronidase inhibitors. D-Saccharic acid 1,4-lactone hydrate possesses anticarcinogenic, detoxifying, and antioxidant properties[1][2]. |
Name | (2S)-2-[(3R,4R)-3,4-dihydroxy-5-oxooxolan-2-yl]-2-hydroxyacetic acid,hydrate |
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Synonym | More Synonyms |
Description | D-Saccharic acid 1,4-lactone hydrate is a potent β-glucuronidase inhibitor (IC50=48.4 μM). D-Saccharic acid 1,4-lactone hydrate can be used as a standard drug compared with novel β-glucuronidase inhibitors. D-Saccharic acid 1,4-lactone hydrate possesses anticarcinogenic, detoxifying, and antioxidant properties[1][2]. |
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Related Catalog | |
References |
Melting Point | 80-82ºC |
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Molecular Formula | C6H10O8 |
Molecular Weight | 192.12400 |
Exact Mass | 192.02700 |
PSA | 124.29000 |
Storage condition | 2-8°C |
Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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RIDADR | NONH for all modes of transport |
HS Code | 2932190090 |
HS Code | 2932190090 |
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Summary | 2932190090 other compounds containing an unfused furan ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0% |
Phase II metabolism in human skin: skin explants show full coverage for glucuronidation, sulfation, N-acetylation, catechol methylation, and glutathione conjugation.
Drug Metab. Dispos. 43(1) , 126-39, (2014) Although skin is the largest organ of the human body, cutaneous drug metabolism is often overlooked, and existing experimental models are insufficiently validated. This proof-of-concept study investig... |
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A High Throughput Assay for Discovery of Bacterial β-Glucuronidase Inhibitors.
Curr. Chem. Genomics 5 , 13-20, (2011) CPT-11 is a widely-used anti-cancer drug that is converted in vivo to its active metabolite, SN-38. In the liver, enzymes detoxify SN-38 by coupling it to a glucuronidate moiety and this inactive comp... |
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Characterization of an MPS I-H knock-in mouse that carries a nonsense mutation analogous to the human IDUA-W402X mutation.
Mol. Genet. Metab. 99(1) , 62-71, (2010) Here we report the characterization of a knock-in mouse model for the autosomal recessive disorder mucopolysaccharidosis type I-Hurler (MPS I-H), also known as Hurler syndrome. MPS I-H is the most sev... |
D-Saccharolactone |
D-Saccharic acid 1,4-lactone monohydrate |
D-Glucaro-1,4-lactone Monohydrate |
1,4-Lactone-D-glucaric Acid Monohydrate |
D-Glucaro-1,4-lacton |
D-Glucaric acid-1,4-lactone |
MFCD00149334 |