Amfenac Sodium Monohydrate

Modify Date: 2024-01-02 09:04:46

Amfenac Sodium Monohydrate Structure
Amfenac Sodium Monohydrate structure
Common Name Amfenac Sodium Monohydrate
CAS Number 61618-27-7 Molecular Weight 295.266
Density N/A Boiling Point 520ºC at 760 mmHg
Molecular Formula C15H14NNaO4 Melting Point 242-244ºC
MSDS N/A Flash Point 268.3ºC

 Use of Amfenac Sodium Monohydrate


Amfenac Sodium Hydrate is a COX-2 inhibitor.

 Names

Name amfenac sodium hydrate
Synonym More Synonyms

 Amfenac Sodium Monohydrate Biological Activity

Description Amfenac Sodium Hydrate is a COX-2 inhibitor.
Related Catalog
Target

COX-2

In Vitro Cells transfected to express COX-2 have a higher proliferation rate than those do not. The addition of Amfenac Sodium Hydrate significantly decreases the proliferation rate of all cell lines. Nitric oxide production by macrophages is inhibited by the addition of melanoma conditioned medium, the addition of Amfenac Sodium Hydrate partially overcomes this inhibition[1]. Results show that Amfenac Sodium Hydrate inhibits the release of B-glucuronidase: 5×10-4 M Amfenac Sodium Hydrate inhibits the release of the enzyme 35.3 and 16.3% in the presence of 10-8, and 10-7 M FMLP, respectively. Addition of 10-4 M Amfenac Sodium Hydrate causes 28.3% inhibition of aggregation of polgmorphonuclear leukocgtes (PMNs) during incubation for 16 min with 10-8 M FMLP[2].
Cell Assay Human uveal melanoma cell lines are transfected to constitutively express COX-2 and the proliferative rate of these cells using two different methods, with and without the addition of Amfenac Sodium Hydrate, is measured. Nitric oxide production by macrophages is measured after exposure to melanoma-conditioned medium from both groups of cells as well as with and without Amfenac Sodium Hydrate[1].
References

[1]. Marshall JC, et al. The effects of a cyclooxygenase-2 (COX-2) expression and inhibition on human uveal melanoma cell proliferation and macrophage nitric oxide production. J Carcinog. 2007 Nov 27;6:17.

[2]. Matsumoto T, et al. Effect of a non-steroidal anti-inflammatory drug (amfenac sodium) on polymorphonuclear leukocytes. Pharmacol Res Commun. 1982 Jun;14(6):523-32.

 Chemical & Physical Properties

Boiling Point 520ºC at 760 mmHg
Melting Point 242-244ºC
Molecular Formula C15H14NNaO4
Molecular Weight 295.266
Flash Point 268.3ºC
Exact Mass 295.082062
PSA 92.45000
LogP 1.30910
Storage condition Refrigerator

 Safety Information

Hazard Codes Xi
HS Code 2922509090

 Customs

HS Code 2922509090
Summary 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Synonyms

Sodium (2-amino-3-benzoylphenyl)acetate hydrate (1:1:1)
Amfenac sodium salt monohydrate
2-Amino-3-benzoylbenzeneacetic acid,monosodium salt,monohydrate
2-Amino-3-benzoylbenzeneacetic acid sodium salt hydrate
sodium,2-(2-amino-3-benzoylphenyl)acetate,hydrate
Benzeneacetic acid, 2-amino-3-benzoyl-, sodium salt, hydrate (1:1:1)
AHR-5850D
Amfenac Sodium Hydrate
Amfenac sodium monohydrate
Fenazox
Amfenac sodium salt hydrate
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