Amfenac Sodium Monohydrate structure
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Common Name | Amfenac Sodium Monohydrate | ||
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CAS Number | 61618-27-7 | Molecular Weight | 295.266 | |
Density | N/A | Boiling Point | 520ºC at 760 mmHg | |
Molecular Formula | C15H14NNaO4 | Melting Point | 242-244ºC | |
MSDS | N/A | Flash Point | 268.3ºC |
Use of Amfenac Sodium MonohydrateAmfenac Sodium Hydrate is a COX-2 inhibitor. |
Name | amfenac sodium hydrate |
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Synonym | More Synonyms |
Description | Amfenac Sodium Hydrate is a COX-2 inhibitor. |
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Related Catalog | |
Target |
COX-2 |
In Vitro | Cells transfected to express COX-2 have a higher proliferation rate than those do not. The addition of Amfenac Sodium Hydrate significantly decreases the proliferation rate of all cell lines. Nitric oxide production by macrophages is inhibited by the addition of melanoma conditioned medium, the addition of Amfenac Sodium Hydrate partially overcomes this inhibition[1]. Results show that Amfenac Sodium Hydrate inhibits the release of B-glucuronidase: 5×10-4 M Amfenac Sodium Hydrate inhibits the release of the enzyme 35.3 and 16.3% in the presence of 10-8, and 10-7 M FMLP, respectively. Addition of 10-4 M Amfenac Sodium Hydrate causes 28.3% inhibition of aggregation of polgmorphonuclear leukocgtes (PMNs) during incubation for 16 min with 10-8 M FMLP[2]. |
Cell Assay | Human uveal melanoma cell lines are transfected to constitutively express COX-2 and the proliferative rate of these cells using two different methods, with and without the addition of Amfenac Sodium Hydrate, is measured. Nitric oxide production by macrophages is measured after exposure to melanoma-conditioned medium from both groups of cells as well as with and without Amfenac Sodium Hydrate[1]. |
References |
Boiling Point | 520ºC at 760 mmHg |
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Melting Point | 242-244ºC |
Molecular Formula | C15H14NNaO4 |
Molecular Weight | 295.266 |
Flash Point | 268.3ºC |
Exact Mass | 295.082062 |
PSA | 92.45000 |
LogP | 1.30910 |
Storage condition | Refrigerator |
Hazard Codes | Xi |
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HS Code | 2922509090 |
HS Code | 2922509090 |
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Summary | 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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