AZD5904

Modify Date: 2024-01-16 16:32:36

AZD5904 Structure
AZD5904 structure
Common Name AZD5904
CAS Number 618913-30-7 Molecular Weight 252.293
Density 1.5±0.1 g/cm3 Boiling Point N/A
Molecular Formula C10H12N4O2S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of AZD5904


AZD5904 is a potent and irreversible inhibitor of human Myeloperoxidase (MPO) with an IC50 of 140 nM and has similar potency in mouse and rat.

 Names

Name AZD 5904
Synonym More Synonyms

 AZD5904 Biological Activity

Description AZD5904 is a potent and irreversible inhibitor of human Myeloperoxidase (MPO) with an IC50 of 140 nM and has similar potency in mouse and rat.
Related Catalog
Target

IC50: 140 nM (human MPO)[1]

In Vitro AZD5904 is a potent and irreversible inhibitor of human Myeloperoxidase (MPO) with an IC50 of 140 nM and has similar potency in mouse and rat. It is 10 to 19-fold selective compare to the closely related lactoperoxidase and thyroid peroxidase; >70-fold to a broad panel of other enzymes, ion channels, and receptors. In isolated human neutrophils, 1 µM AZD5904 inhibits PMA stimulated HOCl by >90%[1].
References

[1]. Myeloperoxidase (MPO) inhibitor.

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Molecular Formula C10H12N4O2S
Molecular Weight 252.293
Exact Mass 252.068100
LogP -1.43
Index of Refraction 1.704
Storage condition 2-8℃

 Synonyms

6H-Purin-6-one, 1,2,3,7-tetrahydro-3-[[(2R)-tetrahydro-2-furanyl]methyl]-2-thioxo-
3-[(2R)-Tetrahydro-2-furanylmethyl]-2-thioxo-1,2,3,7-tetrahydro-6H-purin-6-one
AZD5904
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