618913-30-7

618913-30-7 structure

Name: AZD5904
Chemical Name: AZD 5904
CAS Number: 618913-30-7
Molecular Formula: C₁₀H₁₂N₄O₂S
Molecular Weight: 252.293
Catalog: Research Areas Neurological Disease
Create Date: 2018-03-07 09:07:16
Modify Date: 2024-01-16 16:32:36
AZD5904 is a potent and irreversible inhibitor of human Myeloperoxidase (MPO) with an IC50 of 140 nM and has similar potency in mouse and rat.

Name	AZD 5904
Synonyms	6H-Purin-6-one, 1,2,3,7-tetrahydro-3-[[(2R)-tetrahydro-2-furanyl]methyl]-2-thioxo- 3-[(2R)-Tetrahydro-2-furanylmethyl]-2-thioxo-1,2,3,7-tetrahydro-6H-purin-6-one AZD5904

Description	AZD5904 is a potent and irreversible inhibitor of human Myeloperoxidase (MPO) with an IC50 of 140 nM and has similar potency in mouse and rat.
Related Catalog	Research Areas >> Neurological Disease
Target	IC50: 140 nM (human MPO)[1]
In Vitro	AZD5904 is a potent and irreversible inhibitor of human Myeloperoxidase (MPO) with an IC50 of 140 nM and has similar potency in mouse and rat. It is 10 to 19-fold selective compare to the closely related lactoperoxidase and thyroid peroxidase; >70-fold to a broad panel of other enzymes, ion channels, and receptors. In isolated human neutrophils, 1 µM AZD5904 inhibits PMA stimulated HOCl by >90%[1].
References	[1]. Myeloperoxidase (MPO) inhibitor.