CCG-63802

Modify Date: 2024-01-10 08:51:34

CCG-63802 Structure
CCG-63802 structure
 Common Name CCG-63802
CAS Number 620112-78-9 Molecular Weight 450.51200
Density 1.31 Boiling Point 547.9ºC at 760 mmHg
Molecular Formula C26H18N4O2S Melting Point N/A
MSDS Chinese USA Flash Point 285.1ºC

 Use of CCG-63802


CCG-63802 is a reversible inhibitor of regulator of G-protein signaling (RGS) protein; with greatest potency at RGS4.IC50 value:Target: RGSCCG-63802 is selective amongst RGS proteins, with greatest potency at RGS4. CCG-63802 inhibits GTPase accelerating protein activity of RGS4 and blocks its interaction with Gαo. Retains activity under reducing conditions.

 Names

Name (E)-2-(1,3-benzothiazol-2-yl)-3-[9-methyl-2-(3-methylphenoxy)-4-oxopyrido[1,2-a]pyrimidin-3-yl]prop-2-enenitrile
Synonym More Synonyms

 CCG-63802 Biological Activity

Description CCG-63802 is a reversible inhibitor of regulator of G-protein signaling (RGS) protein; with greatest potency at RGS4.IC50 value:Target: RGSCCG-63802 is selective amongst RGS proteins, with greatest potency at RGS4. CCG-63802 inhibits GTPase accelerating protein activity of RGS4 and blocks its interaction with Gαo. Retains activity under reducing conditions.
Related Catalog
References

[1]. Blazer LL, et al. Reversible, allosteric small-molecule inhibitors of regulator of G protein signaling proteins. Mol Pharmacol. 2010 Sep;78(3):524-33.

[2]. Bosier B, et al. Inhibition of the regulator of G protein signalling RGS4 in the spinal cord decreases neuropathic hyperalgesia and restores cannabinoid CB1 receptor signalling. Br J Pharmacol. 2015 Nov;172(22):5333-46.

[3]. Meng X, et al. PPARγ Agonist PGZ Attenuates OVA-Induced Airway Inflammation and Airway Remodeling via RGS4 Signaling in Mouse Model. Inflammation. 2018 Jul 19.

 Chemical & Physical Properties

Density 1.31
Boiling Point 547.9ºC at 760 mmHg
Molecular Formula C26H18N4O2S
Molecular Weight 450.51200
Flash Point 285.1ºC
Exact Mass 450.11500
PSA 108.52000
LogP 5.77748
Index of Refraction 1.694
Storage condition 2-8℃

 Synonyms

unii-339bu4y35u
hms1804i11
CCG-63802
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Chemsrc provides CCG-63802(CAS#:620112-78-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of CCG-63802 are included as well.>> amp version: CCG-63802

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