THS-044
Modify Date: 2024-01-02 18:53:21
THS-044 structure
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Common Name | THS-044 | ||
|---|---|---|---|---|
| CAS Number | 62054-67-5 | Molecular Weight | 291.227 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 347.1±52.0 °C at 760 mmHg | |
| Molecular Formula | C11H12F3N3O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 163.7±30.7 °C | |
Use of THS-044THS-044 binding stabilizes the HIF2α PAS-B folded state, for regulating HIF2 activity in endogenous and clinical settings.Target: HIF2αLimited trypsin proteolysis reveals that both apo and THS-044-bound protein are efficiently cut at R330 in the extended HI loop. In the THS-044 bound state, there appears no additional proteolysis at the remaining candidate trypsin sites. In contrast, these THS-044-protected sites are protease accessible in the unliganded protein, leading its complete degradation. In parallel, NMR-based deuterium exchange measurements revealed a dramatic stabilization of the THS-044-bound protein β-sheet, with some sites experiencing 100-fold enhanced protection factors relative to the ligand-free protein. |
| Name | THS-044 |
|---|---|
| Synonym | More Synonyms |
| Description | THS-044 binding stabilizes the HIF2α PAS-B folded state, for regulating HIF2 activity in endogenous and clinical settings.Target: HIF2αLimited trypsin proteolysis reveals that both apo and THS-044-bound protein are efficiently cut at R330 in the extended HI loop. In the THS-044 bound state, there appears no additional proteolysis at the remaining candidate trypsin sites. In contrast, these THS-044-protected sites are protease accessible in the unliganded protein, leading its complete degradation. In parallel, NMR-based deuterium exchange measurements revealed a dramatic stabilization of the THS-044-bound protein β-sheet, with some sites experiencing 100-fold enhanced protection factors relative to the ligand-free protein. |
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| Related Catalog | |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 347.1±52.0 °C at 760 mmHg |
| Molecular Formula | C11H12F3N3O3 |
| Molecular Weight | 291.227 |
| Flash Point | 163.7±30.7 °C |
| Exact Mass | 291.083069 |
| LogP | 1.78 |
| Vapour Pressure | 0.0±0.8 mmHg at 25°C |
| Index of Refraction | 1.561 |
| Storage condition | 2-8℃ |
| N-[2-Nitro-4-(trifluoromethyl)phenyl]-4-morpholinamine |
| 4-Morpholinamine, N-[2-nitro-4-(trifluoromethyl)phenyl]- |
| N-[2-nitro-4-(trifluoromethyl)phenyl]morpholin-4-amine |