Docosahexaenoic Acid

Modify Date: 2024-01-02 15:21:02

Docosahexaenoic Acid Structure
Docosahexaenoic Acid structure
 Common Name Docosahexaenoic Acid
CAS Number 6217-54-5 Molecular Weight 328.488
Density 0.9±0.1 g/cm3 Boiling Point 446.7±24.0 °C at 760 mmHg
Molecular Formula C22H32O2 Melting Point -44ºC
MSDS Chinese USA Flash Point 343.4±18.0 °C

 Use of Docosahexaenoic Acid


Docosahexaenoic Acid (DHA) is an omega-3 fatty acid abundantly present brain and retina. It can be obtained directly from fish oil and maternal milk.

 Names

Name all-cis-docosa-4,7,10,13,16,19-hexaenoic acid
Synonym More Synonyms

 Docosahexaenoic Acid Biological Activity

Description Docosahexaenoic Acid (DHA) is an omega-3 fatty acid abundantly present brain and retina. It can be obtained directly from fish oil and maternal milk.
Related Catalog
Target

Human Endogenous Metabolite

In Vitro Docosahexaenoic acid (DHA) is essential for the growth and functional development of the brain in infants. DHA is also required for maintenance of normal brain function in adults. The inclusion of plentiful DHA in the diet improves learning ability and memory[1]. DHA is an essential requirement in every step of brain development like neural cell proliferation, migration, differentiation, synaptogenesis. The multiple double bonds and unique structure allow DHA to impart special membrane characteristics for effective cell signaling. Many development disorders like dyslexia, autism spectrum disorder, attention deficit hyperactivity disorder, schizophrenia etc. are causally related to decreased level of DHA[2]. DHA is a potent RXR ligand inducing robust RXR activation already at low micro molar concentrations. The EC50 for RXRα activation by DHA is about 5-10 μM fatty acid[3].
In Vivo Docosahexaenoic acid administration over 10 weeks significantly reduces the number of reference memory errors, without affecting the number of working memory errors, and significantly increases the docosahexaenoic acid content and the docosahexaenoic acid/arachidonic acid ratio in both the hippocampus and the cerebral cortex[4]. DHA treatment exerts neuroprotective actions on an experimental mouse model of PD. There is a decrease tendency in brain lipid oxidation of MPTP mice but it does not significantly[5].
Animal Admin Rats: Wistar rats are fed a fish oil-deficient diet through three generations. The young (five-week-old) male rats of the third generation are randomLy divided into two groups. Over 10 weeks, one group is perorally administered docosahexaenoic acid dissolved in 5% gum Arabic solution at 300 mg/kg/day; the other group receives a similar volume of vehicle alone. Five weeks after starting the administration, the rats are tested for learning ability related to two types of memory, reference memory and working memory, with the partially (four of eight) baited eight-arm radial maze[4]. Mice: An experimental model of Parkinson's disease is created by four intraperitoneal injections of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) (4×20 mg/kg, at 12 h intervals). Docosahexaenoic acid is given daily by gavage for 4 weeks (36 mg/kg/day). The motor activity of the mice is evaluated via the pole test. The activity of antioxidant enzymes in the brain are determined by spectrophotometric assays and the concentration of thiobarbituric acid-reactive substances (TBARS) are measured as an index of oxidative damage[5].
References

[1]. Horrocks LA, et al. Health benefits of docosahexaenoic acid (DHA). Pharmacol Res. 1999 Sep;40(3):211-25.

[2]. Gharami K, et al. Essential role of docosahexaenoic acid towards development of a smarter brain. Neurochem Int. 2015 Oct;89:51-62.

[3]. Lengqvist J, et al. Polyunsaturated fatty acids including docosahexaenoic and arachidonic acid bind to the retinoid Xreceptor alpha ligand-binding domain. Mol Cell Proteomics. 2004 Jul;3(7):692-703.

[4]. Gamoh S, et al. Chronic administration of docosahexaenoic acid improves reference memory-related learning ability in young rats. Neuroscience. 1999;93(1):237-41.

[5]. Ozsoy O, et al. The influence and the mechanism of docosahexaenoic acid on a mouse model of Parkinson's disease. Neurochem Int. 2011 Oct;59(5):664-70.

 Chemical & Physical Properties

Density 0.9±0.1 g/cm3
Boiling Point 446.7±24.0 °C at 760 mmHg
Melting Point -44ºC
Molecular Formula C22H32O2
Molecular Weight 328.488
Flash Point 343.4±18.0 °C
Exact Mass 328.240234
PSA 37.30000
LogP 6.78
Vapour Pressure 0.0±2.3 mmHg at 25°C
Index of Refraction 1.521
Storage condition −20°C
Stability Light and Air Sensitive

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US)
Safety Phrases S23-S24/25
RIDADR NA 1993 / PGIII
WGK Germany 3
HS Code 2106909090

 Synthetic Route

 Customs

HS Code 2916190090
Summary 2916190090 unsaturated acyclic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:6.5%。general tariff:30.0%

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 Synonyms

Cervonic acid
4Z,7Z,10Z,13Z,16Z,19Z-DHA
docosahexenoic acid
4,7,10,13,16,19-Docosahexaenoic acid, (4E,7E,10Z,13E,16E,19E)-
Cervicarcin,hemihydrate
cis-4,7,10,13,16,19-docosahexaenoic acid
(4E,7E,10Z,13E,16E,19E)-4,7,10,13,16,19-Docosahexaenoic acid
MFCD00065722
Docosahexaenoic Acid
DHA
EINECS 612-950-9
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