Epidermal Growth Factor

Modify Date: 2024-01-02 10:08:42

Epidermal Growth Factor structure	Common Name	Epidermal Growth Factor
	CAS Number	62253-63-8	Molecular Weight	6221.96723999994
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₇₀H₄₀₁N₇₃O₈₃S₇	Melting Point	N/A
	MSDS	USA	Flash Point	N/A

Use of Epidermal Growth Factor

Epidermal growth factor (EGF) is the key regulatory factor in promoting cell survival. Epidermal growth factor (EGF) signaling pathways are related with apoptosis. Loss of Epidermal growth factor (EGF) leads to embryonic or perinatal lethality with abnormalities in multiple organs. Epidermal growth factor (EGF) can stimulate reactive oxygen species (ROS) production for a short period of time in cells. Epidermal growth factor (EGF) can be used to research development and cancer[1][2].

Name	Epidermal Growth Factor
Synonym	More Synonyms

Description	Epidermal growth factor (EGF) is the key regulatory factor in promoting cell survival. Epidermal growth factor (EGF) signaling pathways are related with apoptosis. Loss of Epidermal growth factor (EGF) leads to embryonic or perinatal lethality with abnormalities in multiple organs. Epidermal growth factor (EGF) can stimulate reactive oxygen species (ROS) production for a short period of time in cells. Epidermal growth factor (EGF) can be used to research development and cancer[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
Target	Apoptosis, ROS[1][2]
In Vitro	Epidermal growth factor (EGF) (500 ng/mL; 0-20 min) can induce the production of ROS in A431 cells[1]. Epidermal growth factor (EGF)-induced tyrosine phosphorylation of various cellular proteins was completely blocked in A431 cells containing exogenous catalase[1].
In Vivo	Epidermal growth factor (EGF) (Osmotic pump delivered over 8 days at 10 pg/day) exhibits a highly significant stimulatory effect on wound closure in male mice[3]. Animal Model: C57BL6J and CBA mice (0.5-cm2 full-thickness back wound was cut out of the center of the back)[3] Dosage: 10 μg/day Administration: Osmotic pump delivered over 8 days at 10 pg/day Result: Exhibited a highly significant (P < 0.001) stimulatory effect on wound closure over 6 days in male mice.

Molecular Formula	C₂₇₀H₄₀₁N₇₃O₈₃S₇
Molecular Weight	6221.96723999994
Appearance of Characters	powder
Storage condition	2-8°C

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	KB4518000

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nepidermin

MFCD00132565

EINECS 263-468-7

rh-EGF