DD-01050

Modify Date: 2024-03-28 11:35:12

DD-01050 Structure
DD-01050 structure
Common Name DD-01050
CAS Number 628298-68-0 Molecular Weight 633.396
Density N/A Boiling Point N/A
Molecular Formula C26H33Cl4N7O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of DD-01050


A potent, noncompetitive TRPV1 antagonist that abrogates capsaicin and pH-evoked TRPV1 channel activity with submicromolar activity; preferentially inhibits TRPV1, showing marginal block of other neuronal receptors; inhibits capsaicin-evoked nerve activity in afferent fibers without affecting mechanically activated activity, attenuates carrageenan-induced paw inflammation, without affecting normal nociception in vivo; also decreases the cells in S/G2/M phases in prostate PC3 cells.

 Names

Name DD-01050

 DD-01050 Biological Activity

Description A potent, noncompetitive TRPV1 antagonist that abrogates capsaicin and pH-evoked TRPV1 channel activity with submicromolar activity; preferentially inhibits TRPV1, showing marginal block of other neuronal receptors; inhibits capsaicin-evoked nerve activity in afferent fibers without affecting mechanically activated activity, attenuates carrageenan-induced paw inflammation, without affecting normal nociception in vivo; also decreases the cells in S/G2/M phases in prostate PC3 cells.
References References 1. García-Martínez C, et al. J Pain. 2006 Oct;7(10):735-46. 2. Valero ML, et al. PLoS One. 2012;7(12):e51825. View Related Products by Target TRP Channel

 Chemical & Physical Properties

Molecular Formula C26H33Cl4N7O3
Molecular Weight 633.396