628298-68-0

628298-68-0 structure

Name: DD-01050
Chemical Name: DD-01050
CAS Number: 628298-68-0
Molecular Formula: C₂₆H₃₃Cl₄N₇O₃
Molecular Weight: 633.396
Create Date: 2020-01-12 06:47:51
Modify Date: 2024-03-28 11:35:12
A potent, noncompetitive TRPV1 antagonist that abrogates capsaicin and pH-evoked TRPV1 channel activity with submicromolar activity; preferentially inhibits TRPV1, showing marginal block of other neuronal receptors; inhibits capsaicin-evoked nerve activity in afferent fibers without affecting mechanically activated activity, attenuates carrageenan-induced paw inflammation, without affecting normal nociception in vivo; also decreases the cells in S/G2/M phases in prostate PC3 cells.

Name	DD-01050

Description	A potent, noncompetitive TRPV1 antagonist that abrogates capsaicin and pH-evoked TRPV1 channel activity with submicromolar activity; preferentially inhibits TRPV1, showing marginal block of other neuronal receptors; inhibits capsaicin-evoked nerve activity in afferent fibers without affecting mechanically activated activity, attenuates carrageenan-induced paw inflammation, without affecting normal nociception in vivo; also decreases the cells in S/G2/M phases in prostate PC3 cells.
References	References 1. García-Martínez C, et al. J Pain. 2006 Oct;7(10):735-46. 2. Valero ML, et al. PLoS One. 2012;7(12):e51825. View Related Products by Target TRP Channel

Molecular Formula	C₂₆H₃₃Cl₄N₇O₃
Molecular Weight	633.396