BOC-D-FMK
Modify Date: 2024-01-10 19:29:26
BOC-D-FMK structure
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Common Name | BOC-D-FMK | ||
|---|---|---|---|---|
| CAS Number | 634911-80-1 | Molecular Weight | 263.26 | |
| Density | 1.150 | Boiling Point | N/A | |
| Molecular Formula | C11H18FNO5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of BOC-D-FMKBoc-D-FMK is a cell-permeable, irreversible and broad spectrum caspase inhibitor; inhibits apoptosis stimulated by TNF-α with an IC50 of 39 µM. |
| Name | BOC-D-FMK |
|---|
| Description | Boc-D-FMK is a cell-permeable, irreversible and broad spectrum caspase inhibitor; inhibits apoptosis stimulated by TNF-α with an IC50 of 39 µM. |
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| Related Catalog | |
| Target |
Caspase |
| In Vitro | Apoptosis is a pathway of cell death orchestrated by a family of proteases called caspases. Boc-D-fmk inhibits TNFα-stimulated reactive oxygen species (ROS) generation. Boc-D-FMK inhibits apoptosis stimulated by TNF-α with an IC50 of 39 µM[1]. BocD-fmk at 50 µM prevents genistein-induced apoptosis of p815 cells. Confocal microscopy shows that the release of mitochondrial apoptotic factors is inhibited by BocD-fmk[2]. |
| In Vivo | Boc-D-FMK-fmk effectively attenuates the hepatocyte apoptosis in bile duct-ligated rats and may improve the survival rates after endotoxin challenge[3]. A single injection of Boc-D-FMK results in longterm protection of MNs against root avulsion-induced death for more than 8 weeks and the Boc-D-FMK-treated MNs are able to regenerate their axons into an implanted PN graft and reinnervate the target muscle[4]. |
| Animal Admin | Rats: Boc-D-FMK is dissolved in DMSO. Male Sprague-Dawley rats group 1 (OBBOC-D) undergo common bile duct ligation and simultaneously treatment with Boc-D-FMK. The first dose of Boc-D-FMK (1.5 mg/kg) is injected into the inferior vena cava immediately after bile duct ligation. Subsequent doses of Boc-DFMK (1.5 mg/kg twice daily) are given intraperitoneally on the first and second postoperative days. The last dose (1.5 mg/kg) is given on the morning of the third postoperative day[3]. |
| References |
| Density | 1.150 |
|---|---|
| Molecular Formula | C11H18FNO5 |
| Molecular Weight | 263.26 |
| Storage condition | 2-8℃ |