B7/CD28 interaction inhibitor 1
Modify Date: 2024-04-03 12:23:33
B7/CD28 interaction inhibitor 1 structure
|
Common Name | B7/CD28 interaction inhibitor 1 | ||
|---|---|---|---|---|
| CAS Number | 635324-72-0 | Molecular Weight | 427.354 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 599.5±60.0 °C at 760 mmHg | |
| Molecular Formula | C21H13F4N5O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 316.4±32.9 °C | |
Use of B7/CD28 interaction inhibitor 1B7/CD28 interaction inhibitor 1 is a potent B7.1-CD28 interaction inhibitor with an IC50 of 50 nM[1]. |
| Name | 2-(4-Fluorophenyl)-6-methyl-4-[3-(trifluoromethyl)phenyl]-1,6-dihydrodipyrazolo[3,4-b:3',4'-d]pyridin-3(2H)-one |
|---|---|
| Synonym | More Synonyms |
| Description | B7/CD28 interaction inhibitor 1 is a potent B7.1-CD28 interaction inhibitor with an IC50 of 50 nM[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 50 nM (B7.1-CD28 interaction)[1] |
| In Vitro | Bivalent CTLA4 homodimers bridge bivalent B7.1 homodimers to form an unusually stable signaling complex. Blocking B7/CD28 interactions with monoclonal antibodies or soluble receptors results in immunosuppression and enhanced allograft survival, while B7/CTLA-4 blockade results in enhanced antitumor immune responses. The interaction of co-stimulatory molecules on T cells with B7 molecules on antigen presenting cells plays an important role in the activation of naive T cells. Consequently, agents that disrupt these interactions should have applications in treatment of transplant rejection as well as autoimmune diseases[1]. |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 599.5±60.0 °C at 760 mmHg |
| Molecular Formula | C21H13F4N5O |
| Molecular Weight | 427.354 |
| Flash Point | 316.4±32.9 °C |
| Exact Mass | 427.105621 |
| LogP | 3.80 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.677 |
| Storage condition | -20℃ |
| Dipyrazolo[3,4-b:3',4'-d]pyridin-3(2H)-one, 2-(4-fluorophenyl)-1,6-dihydro-6-methyl-4-[3-(trifluoromethyl)phenyl]- |
| 2-(4-Fluorophenyl)-6-methyl-4-[3-(trifluoromethyl)phenyl]-1,6-dihydrodipyrazolo[3,4-b:3',4'-d]pyridin-3(2H)-one |
| CTLA-4 - INHIBITOR |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: B7/CD28 interaction inhibitor 1
- Price: Click To Check
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Yang
- Email: sales@echemcloud.com
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: B7/CD28 interaction inhibitor 1
- Price: ￥576.0/5mg ￥926.0/10mg ￥2806.0/50mg ￥1866.0/25mg
- Purity: 97.0%
- Delivery: 1 Day
- Contact: Liu jia
- Email: 2130147988@qq.com
- DC Chemicals Limited
- China
- Product Name: CTLA-4 inhibitor
- Price: $350.0/10mg $600.0/25mg $1300.0/100mg
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: CTLA-4 inhibitor
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Delivery: 1 Day
- Contact: Tony Lai
- Email: order@dcchemicals.com
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: 2-(4-fluorophenyl)-6-methyl-4-(3-(trifluoromethyl)phenyl)-1,2-dihydrodipyrazolo[3,4-b:3',4'-d]pyridin-3(6H)-one
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Delivery: Inquiry
- Contact: Ms Wang
- Email: enquiry@dycnchem.com
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