Etimizol
Modify Date: 2024-01-07 17:41:53
Etimizol structure
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Common Name | Etimizol | ||
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| CAS Number | 64-99-3 | Molecular Weight | 210.23300 | |
| Density | 1.26g/cm3 | Boiling Point | 563.4ºC at 760 mmHg | |
| Molecular Formula | C9H14N4O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 294.5ºC | |
Use of EtimizolEtimizol(Ethymisole; Antiffine; Ethylnorantifein) was shown to relieve amnesia effectively in the origin of which there is the hypoxic component (hypobaric hypoxia, actinomycin D, mechanical injury of the brain). IC50 Value: Target: Etimizol has a catalytic effect on the respiratory center and belongs to the group of respiratory analeptics, however, it activates adrenokortikotropnuyu pituitary function, which leads to increased levels of glucocorticosteroids in the blood. There is also evidence that short etimizol improves memory and increases mental performance.in vitro:in vivo: The time interval between administration ofetimizol (3 mg/kg) and the onset of learning varied between 0.5 and 3 h in the several series. Etimizol did not facilitate the learning in rats whatever the time of administration and biological modality of reinforcement [1]. After administration of etimizol at doses of 10 or 1 mg/loop mean residence time of etimizol in the loop was 20.1 and 7.6 min, respectively, with mean standard deviation being 3.1 and 0.8, respectively [2]. Extracellular application of 5--10 mM/L etimizol exerted a specific effect on the giant neurons of the Coretus corneus isolated nervous system: action potential duration increased significantly, speed of development of its descending phase decreased, as well as the trace hyperpolarization amplitude [3]. |
| Name | 1-ethyl-4-N,5-N-dimethylimidazole-4,5-dicarboxamide |
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| Synonym | More Synonyms |
| Description | Etimizol(Ethymisole; Antiffine; Ethylnorantifein) was shown to relieve amnesia effectively in the origin of which there is the hypoxic component (hypobaric hypoxia, actinomycin D, mechanical injury of the brain). IC50 Value: Target: Etimizol has a catalytic effect on the respiratory center and belongs to the group of respiratory analeptics, however, it activates adrenokortikotropnuyu pituitary function, which leads to increased levels of glucocorticosteroids in the blood. There is also evidence that short etimizol improves memory and increases mental performance.in vitro:in vivo: The time interval between administration ofetimizol (3 mg/kg) and the onset of learning varied between 0.5 and 3 h in the several series. Etimizol did not facilitate the learning in rats whatever the time of administration and biological modality of reinforcement [1]. After administration of etimizol at doses of 10 or 1 mg/loop mean residence time of etimizol in the loop was 20.1 and 7.6 min, respectively, with mean standard deviation being 3.1 and 0.8, respectively [2]. Extracellular application of 5--10 mM/L etimizol exerted a specific effect on the giant neurons of the Coretus corneus isolated nervous system: action potential duration increased significantly, speed of development of its descending phase decreased, as well as the trace hyperpolarization amplitude [3]. |
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| Related Catalog | |
| References |
| Density | 1.26g/cm3 |
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| Boiling Point | 563.4ºC at 760 mmHg |
| Molecular Formula | C9H14N4O2 |
| Molecular Weight | 210.23300 |
| Flash Point | 294.5ºC |
| Exact Mass | 210.11200 |
| PSA | 83.00000 |
| LogP | 0.77180 |
| Index of Refraction | 1.586 |
| Storage condition | -20°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| HS Code | 2934999090 |
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| HS Code | 2934999090 |
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| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| aethimizolum |
| Ethimizol |
| Ethymisol |
| 1-ethyl-1H-imidazole-4,5-dicarboxylic acid bis-methylamide |
| Ethymysol |
| 1 ethyl 4,5 bis(methylcarbamoyl)imidazole |
| Ethylnorantefein |
| Etimyzol |
| 1-ethyl-4,5-di(N-methylcarbamoyl)-imidazole |
| Antiffine |
| Ethimizole |
| Ethymisole |
| 1-ethylimidazole-4,5-dicarboxylic acid di(methylamide) |
| Ethymazol |
| ETIMIZOL |