Guanethidine sulfate

Modify Date: 2024-01-01 18:33:45

Guanethidine sulfate Structure
Guanethidine sulfate structure
Common Name Guanethidine sulfate
CAS Number 645-43-2 Molecular Weight 296.387
Density N/A Boiling Point 345.6ºC at 760 mmHg
Molecular Formula C10H24N4O4S Melting Point N/A
MSDS N/A Flash Point 162.8ºC
Symbol GHS07
GHS07
Signal Word Warning

 Use of Guanethidine sulfate


Guanethidine is an antihypertensive drug that reduces the release of catecholamines, such as norepinephrine.IC50 value:Target: Guanethidine is transported across the sympathetic nerve membrane by the same mechanism that transports norepinephrine itself (NET, uptake 1), and uptake is essential for the drug's action. Once guanethidine has entered the nerve, it is concentrated in transmitter vesicles, where it replaces norepinephrine.It may also inhibit the release of granules by decreasing norepinephrine.

 Names

Name guanethidine monosulfate
Synonym More Synonyms

 Guanethidine sulfate Biological Activity

Description Guanethidine is an antihypertensive drug that reduces the release of catecholamines, such as norepinephrine.IC50 value:Target: Guanethidine is transported across the sympathetic nerve membrane by the same mechanism that transports norepinephrine itself (NET, uptake 1), and uptake is essential for the drug's action. Once guanethidine has entered the nerve, it is concentrated in transmitter vesicles, where it replaces norepinephrine.It may also inhibit the release of granules by decreasing norepinephrine.
Related Catalog
References

[1]. Fabiani ME, et al. Inhibition of sympathetic noradrenergic transmission by guanabenz and guanethidine in rat isolated mesenteric artery: involvement of neuronal potassium channels. Pharmacol Res. 1996 Mar;33(3):171-80.

[2]. Joyce PI, et al. The effect of guanethidine and local anesthetics on the electrically stimulated mouse vas deferens. Anesth Analg. 2002 Nov;95(5):1339-43.

 Chemical & Physical Properties

Boiling Point 345.6ºC at 760 mmHg
Molecular Formula C10H24N4O4S
Molecular Weight 296.387
Flash Point 162.8ºC
Exact Mass 296.151825
PSA 148.12000
LogP 2.29240
Storage condition -20°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MF3150000
CAS REGISTRY NUMBER :
645-43-2
LAST UPDATED :
198809
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C10-H22-N4.H2-O4-S
MOLECULAR WEIGHT :
296.44
WISWESSER LINE NOTATION :
T8NTJ A2MYZUM &S-O4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Human
REFERENCE :
BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 4,592,1967 ** ACUTE TOXICITY DATA **
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
REFERENCE :
ARPMAS Archiv der Pharmazie (Weinheim, Germany) (VCH Pub., Inc., 303 NW 12th Ave., Deerfield Beach, FL 33441) V.51-261, 1835-1923; V.305- 1972- Volume(issue)/page/year: 321,57,1988
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
180 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 111,353,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
18500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 111,353,1972

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
Precautionary Statements P301 + P312 + P330
Hazard Codes Xn: Harmful;
Risk Phrases R22
Safety Phrases S25-S36
RIDADR NONH for all modes of transport
RTECS MF3150000
HS Code 2933990090

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

1-[2-(Azocan-1-yl)ethyl]guanidine sulfate (1:1)
EINECS 211-442-0
Iporal
Guanethidine bisulfate
1-[2-(1-Azocanyl)ethyl]guanidine sulfate
Guanidine, N-[2-(hexahydro-1(2H)-azocinyl)ethyl]-, sulfate (1:1)
2-[2-(azocan-1-yl)ethyl]guanidine,sulfuric acid
Sanotensin
MFCD00035403
1-[2-(1-Azocanyl)ethyl]guanidine sulfate (1:1)
1-[2-(Azocan-1-yl)ethyl]guanidine sulfate
Guanethidine Sulfate
Ismelin sulfate
UNII-5UBY8Y002G
Guanetidin sulfate
Guanethidine monosulfate
1-[2-(Azocan-1-yl)ethyl]guanidinsulfat
N-(2-Guanidino ethyl)heptamethylenimine sulfate
1-(2-azocan-1-ylethyl)guanidine sulfate
Ismelin
guanethidine sulphate
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