Bouvardin,5-(N-methyl-L-tyrosine)- (9CI)

Modify Date: 2024-01-10 13:16:22

Bouvardin,5-(N-methyl-L-tyrosine)- (9CI) Structure
Bouvardin,5-(N-methyl-L-tyrosine)- (9CI) structure
Common Name Bouvardin,5-(N-methyl-L-tyrosine)- (9CI)
CAS Number 64725-24-2 Molecular Weight 756.84400
Density 1.189g/cm3 Boiling Point 1083.3ºC at 760mmHg
Molecular Formula C40H48N6O9 Melting Point N/A
MSDS N/A Flash Point 609ºC

 Use of Bouvardin,5-(N-methyl-L-tyrosine)- (9CI)


RA-V is a cyclic hexapeptide. RA-V has activity against Wnt, Myc and Notch with IC50 values of 50, 75, and 93 ng/mL, respectively. RA-V can be used for the research of cancer-related signaling pathways.

 Names

Name deoxyBouvardin
Synonym More Synonyms

 Bouvardin,5-(N-methyl-L-tyrosine)- (9CI) Biological Activity

Description RA-V is a cyclic hexapeptide. RA-V has activity against Wnt, Myc and Notch with IC50 values of 50, 75, and 93 ng/mL, respectively. RA-V can be used for the research of cancer-related signaling pathways.
Related Catalog
Target

IC50: 50 ng/mL (Wnt); 75 ng/mL (Myc), 93 ng/mL (Notch)[1]

In Vivo RA-V 对 Wnt、Myc 和 Notch 具有活性,IC50 值分别为 50、75 和 93 ng/mL[1]。
References

[1]. Premalatha Balachandran, et al. Crosstalk of Cancer Signaling Pathways by Cyclic Hexapeptides and Anthraquinones from Rubia cordifolia. Molecules. 2021 Jan 31;26(3):735.  

 Chemical & Physical Properties

Density 1.189g/cm3
Boiling Point 1083.3ºC at 760mmHg
Molecular Formula C40H48N6O9
Molecular Weight 756.84400
Flash Point 609ºC
Exact Mass 756.34800
PSA 186.92000
LogP 2.34320
Index of Refraction 1.544

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
ED9610000
CAS REGISTRY NUMBER :
64725-24-2
LAST UPDATED :
198702
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C40-H48-N6-O9.5/4H2-O

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
16 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 32,3216,1984
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
34 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 32,3216,1984

 Synthetic Route

 Synonyms

Desoxybenzoin-semicarbazon
1,2-diphenyl-ethanone semicarbazone
Semicarbazon des Phenyl-benzyl-ketons
deoxybouvadin
Benzyl-phenyl-keton-semicarbazon
1,2-Diphenyl-1-semicarbazonoethan
deoxybenzoin semicarbazone
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