Bometolol Hydrochloride
Modify Date: 2024-01-02 20:09:04
Bometolol Hydrochloride structure
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Common Name | Bometolol Hydrochloride | ||
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| CAS Number | 65023-16-7 | Molecular Weight | 508.99 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C25H33ClN2O7 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Bometolol HydrochlorideBometolol Hydrochloride is a beta-adrenergic blocking agent, used for the research of cardiovascular disease. |
| Name | Bometolol Hydrochloride |
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| Description | Bometolol Hydrochloride is a beta-adrenergic blocking agent, used for the research of cardiovascular disease. |
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| Related Catalog | |
| Target |
Beta-adrenergic receptor[1] |
| In Vivo | Bometolol (10-30 mg/kg, p.o.) lowers the blood pressure dose-dependently in spontaneously hypertensive rats, deoxycorticosterone and salt hypertensive rats and two kindey, one clip hypertensive rats. In subchronic study, Bometolol (10-30 mg/kg, or 100-300 mg/kg, p.o.) dose-dependently decreases heart rate, plasma renin activity, heart and kindey weitht and incidence of vascular lesion, but shows no antihypertensive effects in all the hypertensive rats[1]. |
| Animal Admin | Rats[1] In the acute experments, normal female Donryu strain (DON, 14-15 weeks, 250-270 g), and SHR (17-18 weeks, 180-200 g), DOC (7-9 weeks, 180-210 g), and CLIP (7-9 weeks, 180-210 g) hypertensive rats are used. Bometolol hydrochloride is dissolved in H2O and 0.01% Tween 80 solution at a volume of 5 mL/kg body weight for the acute and subchronic studies, respectively. The doses are in terms of the free base. The solution is administratered orally by a gastric tube. In the acute experiment, H2O (5 mL/kg) is giver to the control groups. In the subchronic experment, the drug is administered once a day for 5 weeks, 5 days per week, and Tween 80 solution (5 mL/kg) is given to the control groups[1]. |
| References |
| Molecular Formula | C25H33ClN2O7 |
|---|---|
| Molecular Weight | 508.99 |
| Storage condition | 2-8℃ |