12,14-Dichlorodehydroabietic acid
Modify Date: 2024-01-11 20:01:53
12,14-Dichlorodehydroabietic acid structure
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Common Name | 12,14-Dichlorodehydroabietic acid | ||
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| CAS Number | 65281-77-8 | Molecular Weight | 369.32500 | |
| Density | 1.2g/cm3 | Boiling Point | 469.6ºC at 760 mmHg | |
| Molecular Formula | C20H26Cl2O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 237.8ºC | |
Use of 12,14-Dichlorodehydroabietic acid12,14-Dichlorodehydroabietic acid, a chlorinated resin acid, is a potent Ca2+-activated K+ (BK) channel opener. 12,14-Dichlorodehydroabietic acid blocks GABA-dependent chloride entry in mammalian brain and operates as a non-competitive GABAA antagonist. 12,14-Dichlorodehydroabietic acid increases cytosolic free Ca2+ and stimulates transmitter release[1][2]. |
| Name | (1R,4aS,10aR)-6,8-dichloro-1,4a-dimethyl-7-propan-2-yl-2,3,4,9,10,10a-hexahydrophenanthrene-1-carboxylic acid |
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| Synonym | More Synonyms |
| Description | 12,14-Dichlorodehydroabietic acid, a chlorinated resin acid, is a potent Ca2+-activated K+ (BK) channel opener. 12,14-Dichlorodehydroabietic acid blocks GABA-dependent chloride entry in mammalian brain and operates as a non-competitive GABAA antagonist. 12,14-Dichlorodehydroabietic acid increases cytosolic free Ca2+ and stimulates transmitter release[1][2]. |
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| Related Catalog | |
| Target |
Ca2+-activated K+ (BK) channel[2] GABAA[1] |
| References |
| Density | 1.2g/cm3 |
|---|---|
| Boiling Point | 469.6ºC at 760 mmHg |
| Molecular Formula | C20H26Cl2O2 |
| Molecular Weight | 369.32500 |
| Flash Point | 237.8ºC |
| Exact Mass | 368.13100 |
| PSA | 37.30000 |
| LogP | 6.21170 |
| Index of Refraction | 1.555 |
| 12,14-DICHLORODEHYDROABIETIC ACID |
| 1-Phenanthrenecarboxylic acid,6,8-dichloro-1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-(1-methylethyl)-,(1R,4aS,10aR) |