4'',5''-Dehydroisopsoralidin

Modify Date: 2024-01-14 08:52:08

4'',5''-Dehydroisopsoralidin structure	Common Name	4'',5''-Dehydroisopsoralidin
	CAS Number	65639-51-2	Molecular Weight	334.32
	Density	1.401±0.06 g/cm3	Boiling Point	432.4±45.0 °C
	Molecular Formula	C₂₀H₁₄O₅	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of 4'',5''-Dehydroisopsoralidin

4'',5''-Dehydroisopsoralidin is a β-glucuronidase inhibitor (IC50: 6.3 μM). 4'',5''-Dehydroisopsoralidin has anti-inflammatory and anti-oxidative effects. 4'',5''-Dehydroisopsoralidin can be used in the research of inflammation and cancners[1][2].

Name	4′′,5′′-dehydroisopsoralidin

Description	4'',5''-Dehydroisopsoralidin is a β-glucuronidase inhibitor (IC50: 6.3 μM). 4'',5''-Dehydroisopsoralidin has anti-inflammatory and anti-oxidative effects. 4'',5''-Dehydroisopsoralidin can be used in the research of inflammation and cancners[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
Target	β-glucuronidase[1]
In Vitro	4'',5''-Dehydroisopsoralidin (compound 5, 15 min) inhibits the release of β-glucuronidase in polymorphonuclear leukocytes (PMNs) of rats, with an IC50 value of 6.3 μM[1]. 4'',5''-Dehydroisopsoralidin (compound 9, 24 h) shows weak cytotoxicity (IC50: >50 μM) to H4IIE, HCT116, C6 cells[2]. 4'',5''-Dehydroisopsoralidin (25 μM, 1h) causes significant radical scavenging in H4IIE rat hepatoma cells (TEAC assay)[2]. 4'',5''-Dehydroisopsoralidin (compound 5, 15 μM, 60 h) increases lifespan in P. corylifolia (MEP assay)[3].
References	[1]. De-Wu Zhang, et al. Solalyratins A and B, new anti-inflammatory metabolites from Solanum lyratum. J Nat Med. 2012 Apr;66(2):362-6. [2]. Christian Limper, et al. Compounds isolated from Psoralea corylifolia seeds inhibit protein kinase activity and induce apoptotic cell death in mammalian cells. J Pharm Pharmacol. 2013 Sep;65(9):1393-408. [3]. Tong-Hong Wang, et al. The flavonoid corylin exhibits lifespan extension properties in mouse. Nat Commun. 2022 Mar 9;13(1):1238.

Density	1.401±0.06 g/cm3
Boiling Point	432.4±45.0 °C
Molecular Formula	C₂₀H₁₄O₅
Molecular Weight	334.32

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 4'',5''-Dehydroisopsoralidin
Price: Negotiable
Purity: 93.0%
Delivery: 10 Day
Contact: Huang
Email: sales@echemcloud.com

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