1,10-Phenanthroline

Modify Date: 2024-01-02 05:29:52

1,10-Phenanthroline Structure
1,10-Phenanthroline structure
Common Name 1,10-Phenanthroline
CAS Number 66-71-7 Molecular Weight 180.205
Density 1.3±0.1 g/cm3 Boiling Point 365.1±15.0 °C at 760 mmHg
Molecular Formula C12H8N2 Melting Point 114-117 °C(lit.)
MSDS Chinese USA Flash Point 164.8±11.7 °C
Symbol GHS06 GHS09
GHS06, GHS09
Signal Word Danger

 Use of 1,10-Phenanthroline


o-Phenanthroline (1,10-Phenanthroline), a metal chelator, prevents the induction of chromosomal aberrations in streptozotocin-treated cells. o-Phenanthroline (1,10-Phenanthroline) forms a red chelate with Fe2+ that absorbs maximally at 510 nm[1].

 Names

Name 1,10-phenanthroline
Synonym More Synonyms

 1,10-Phenanthroline Biological Activity

Description o-Phenanthroline (1,10-Phenanthroline), a metal chelator, prevents the induction of chromosomal aberrations in streptozotocin-treated cells. o-Phenanthroline (1,10-Phenanthroline) forms a red chelate with Fe2+ that absorbs maximally at 510 nm[1].
Related Catalog
References

[1]. Guan NanMu, et al. Synergistic inhibition between o-phenanthroline and chloride ion on cold rolled steel corrosion in phosphoric acid. Materials Chemistry and Physics Volume 86, Issue 1, 15 July 2004, Pages 59-68.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 365.1±15.0 °C at 760 mmHg
Melting Point 114-117 °C(lit.)
Molecular Formula C12H8N2
Molecular Weight 180.205
Flash Point 164.8±11.7 °C
Exact Mass 180.068741
PSA 25.78000
LogP 1.78
Vapour Pressure 0.0±0.8 mmHg at 25°C
Index of Refraction 1.740
Storage condition Refrigerator
Stability Stable. Hygroscopic. Store under nitrogen. Incompatible with strong acids, strong oxidizing agents.
Water Solubility slightly soluble

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SF8300000
CHEMICAL NAME :
1,10-Phenanthroline
CAS REGISTRY NUMBER :
66-71-7
LAST UPDATED :
199701
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C12-H8-N2
MOLECULAR WEIGHT :
180.22
WISWESSER LINE NOTATION :
T B666 CN NNJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
75 mg/kg
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes in urine composition Kidney, Ureter, Bladder - other changes
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
18 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
30 mg/kg
SEX/DURATION :
female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system

MUTATION DATA

TYPE OF TEST :
DNA inhibition
TEST SYSTEM :
Human Leukocyte
DOSE/DURATION :
5 mg/L
REFERENCE :
ONCOBS Oncology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.21- 1967- Volume(issue)/page/year: 46,193,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82276 No. of Facilities: 1002 (estimated) No. of Industries: 12 No. of Occupations: 11 No. of Employees: 8324 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 82276 No. of Facilities: 2265 (estimated) No. of Industries: 33 No. of Occupations: 35 No. of Employees: 40330 (estimated) No. of Female Employees: 2577 (estimated)

 Safety Information

Symbol GHS06 GHS09
GHS06, GHS09
Signal Word Danger
Hazard Statements H301-H410
Precautionary Statements P273-P301 + P310-P501
Personal Protective Equipment Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes T:Toxic
Risk Phrases R25;R50/53
Safety Phrases S45-S60-S61
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
RTECS SF8437000
Packaging Group III
Hazard Class 6.1
HS Code 29339990

 Synthetic Route

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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 Synonyms

1,10-Phenanthroline
4,5-Diazaphenanthrene
4,5-Phenanthroline
ORTHOPHENANTHROLINE
EINECS 200-629-2
1,10-o-Phenanthroline
o-Phenanthroline
β-Phenanthroline
1,10-Fenanthroline
phenanthroline
MFCD00011678
1,10-Fenanthrolin
phen
10-Phenanthroline
T B666 CN NNJ
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