4-tert-butyl-2-((cyclohexylamino)methyl)-6-methylphenol

Modify Date: 2024-01-09 18:33:16

4-tert-butyl-2-((cyclohexylamino)methyl)-6-methylphenol Structure
4-tert-butyl-2-((cyclohexylamino)methyl)-6-methylphenol structure
Common Name 4-tert-butyl-2-((cyclohexylamino)methyl)-6-methylphenol
CAS Number 6640-90-0 Molecular Weight 275.42900
Density 1g/cm3 Boiling Point 387.3ºC at 760 mmHg
Molecular Formula C18H29NO Melting Point N/A
MSDS N/A Flash Point 67.2ºC

 Use of 4-tert-butyl-2-((cyclohexylamino)methyl)-6-methylphenol


NSC 48160 inhibits the growth of the pancreatic cancer cells with IC50s of 84.3 μM for CPFAC-1 and 94.5 μM for BxPC-3. NSC 48160 also induces pancreatic cancer cell apoptosis. NSC 48160 can improve metabolic syndromes, such as NASH, obesity and lipid metabolism disorders[1][2].

 Names

Name 4-tert-butyl-2-[(cyclohexylamino)methyl]-6-methylphenol
Synonym More Synonyms

  Biological Activity

Description NSC 48160 inhibits the growth of the pancreatic cancer cells with IC50s of 84.3 μM for CPFAC-1 and 94.5 μM for BxPC-3. NSC 48160 also induces pancreatic cancer cell apoptosis. NSC 48160 can improve metabolic syndromes, such as NASH, obesity and lipid metabolism disorders[1][2].
Related Catalog
References

[1]. Li D, et al. A small-molecule induces apoptosis and suppresses metastasis in pancreatic cancer cells. Eur J Pharm Sci. 2013 Mar 12;48(4-5):658-67.  

[2]. Liu zuijia, et al. Application of small molecule compound NSC48160 in preparation of medicine for treating non-alcoholic fatty liver disease. Patent. CN115869292

 Chemical & Physical Properties

Density 1g/cm3
Boiling Point 387.3ºC at 760 mmHg
Molecular Formula C18H29NO
Molecular Weight 275.42900
Flash Point 67.2ºC
Exact Mass 275.22500
PSA 32.26000
LogP 4.81130
Index of Refraction 1.538

 Synthetic Route

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4-tert-butyl-2-((cyclohexylamino)methyl)-6-methylphenol Structure

4-tert-butyl-2-...

CAS#:6640-90-0

Literature: Burke et al. Journal of the American Chemical Society, 1958 , vol. 80, p. 3438,3443

~%

4-tert-butyl-2-((cyclohexylamino)methyl)-6-methylphenol Structure

4-tert-butyl-2-...

CAS#:6640-90-0

Literature: Burke et al. Journal of the American Chemical Society, 1958 , vol. 80, p. 3438,3443

~%

4-tert-butyl-2-((cyclohexylamino)methyl)-6-methylphenol Structure

4-tert-butyl-2-...

CAS#:6640-90-0

Literature: Burke et al. Journal of the American Chemical Society, 1958 , vol. 80, p. 3438,3443

 Synonyms

4-tert-Butyl-2-cyclohexylaminomethyl-6-methyl-phenol