Melatonin D5

Modify Date: 2024-01-03 12:26:36

Melatonin D5 structure	Common Name	Melatonin D5
	CAS Number	66521-38-8	Molecular Weight	236.30300
	Density	1.196g/cm3	Boiling Point	512.831ºC at 760 mmHg
	Molecular Formula	C₁₃H₁₂D₄N₂O₂	Melting Point	117-118ºC
	MSDS	N/A	Flash Point	263.951ºC

Use of Melatonin D5

Melatonin D5 is deuterium labeled Melatonin. Melatonin is a hormone made by the pineal gland that can activates melatonin receptor. Antioxidative and anti-inflammatory properties[1][2][3]. Melatonin is a selective ATF-6 inhibitor and induces human hepatoma cell apoptosis through COX-2 downregulation[4].

Name	Melatonin-d4
Synonym	More Synonyms

Description	Melatonin D5 is deuterium labeled Melatonin. Melatonin is a hormone made by the pineal gland that can activates melatonin receptor. Antioxidative and anti-inflammatory properties[1][2][3]. Melatonin is a selective ATF-6 inhibitor and induces human hepatoma cell apoptosis through COX-2 downregulation[4].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Neuronal Signaling >> Melatonin Receptor Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> GPCR/G Protein >> Melatonin Receptor Research Areas >> Inflammation/Immunology Signaling Pathways >> Autophagy >> Mitophagy Research Areas >> Neurological Disease
References	[1]. Kilic U, et al. Particular phosphorylation of PI3K/Akt on Thr308 via PDK-1 and PTEN mediates melatonin's neuroprotective activity after focal cerebral ischemia in mice. Redox Biol. 2017 Apr 5;12:657-665 [2]. Hu C, et al. Neuroprotective effect of melatonin on soluble Aβ1-42-induced cortical neurodegeneration via Reelin-Dab1 signaling pathway. Neurol Res. 2017 Apr 7:1-1 [3]. Rahim I, et al. Melatonin administration to wild-type mice and non-treated NLRP3 mutant mice share similar inhibition of the inflammatory response during sepsis. J Pineal Res. 2017 Mar 31 [4]. Bu LJ, et al. Melatonin, a novel selective ATF-6 inhibitor, induces human hepatoma cell apoptosis through COX-2 downregulation. World J Gastroenterol. 2017 Feb 14;23(6):986-998.

Description

Related Catalog

Research Areas >> Cancer

Signaling Pathways >> Neuronal Signaling >> Melatonin Receptor

Signaling Pathways >> Autophagy >> Autophagy

Signaling Pathways >> GPCR/G Protein >> Melatonin Receptor

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Autophagy >> Mitophagy

Research Areas >> Neurological Disease

References

[1]. Kilic U, et al. Particular phosphorylation of PI3K/Akt on Thr308 via PDK-1 and PTEN mediates melatonin's neuroprotective activity after focal cerebral ischemia in mice. Redox Biol. 2017 Apr 5;12:657-665

[2]. Hu C, et al. Neuroprotective effect of melatonin on soluble Aβ1-42-induced cortical neurodegeneration via Reelin-Dab1 signaling pathway. Neurol Res. 2017 Apr 7:1-1

[3]. Rahim I, et al. Melatonin administration to wild-type mice and non-treated NLRP3 mutant mice share similar inhibition of the inflammatory response during sepsis. J Pineal Res. 2017 Mar 31

[4]. Bu LJ, et al. Melatonin, a novel selective ATF-6 inhibitor, induces human hepatoma cell apoptosis through COX-2 downregulation. World J Gastroenterol. 2017 Feb 14;23(6):986-998.

Density	1.196g/cm3
Boiling Point	512.831ºC at 760 mmHg
Melting Point	117-118ºC
Molecular Formula	C₁₃H₁₂D₄N₂O₂
Molecular Weight	236.30300
Flash Point	263.951ºC
Exact Mass	236.14600
PSA	54.12000
LogP	2.24600
Index of Refraction	1.6
Storage condition	-20C

N-[1,1,2,2-tetradeuterio-2-(5-methoxy-1H-indol-3-yl)ethyl]acetamide

Melatonin D5

Use of Melatonin D5

Names

Melatonin D5 Biological Activity

Chemical & Physical Properties

Synonyms