Practolol structure
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Common Name | Practolol | ||
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CAS Number | 6673-35-4 | Molecular Weight | 266.33600 | |
Density | 1.0807 (rough estimate) | Boiling Point | 409.54°C (rough estimate) | |
Molecular Formula | C14H22N2O3 | Melting Point | 134-136° (BuOAc) | |
MSDS | Chinese USA | Flash Point | N/A |
Use of PractololPractolol is a potent and selective β1-adrenergic receptor antagonist. Practolol can be used for the research of cardiac arrhythmias[1][2][3]. |
Name | practolol |
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Synonym | More Synonyms |
Description | Practolol is a potent and selective β1-adrenergic receptor antagonist. Practolol can be used for the research of cardiac arrhythmias[1][2][3]. |
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Related Catalog | |
Target |
β1-adrenergic receptor[1] |
In Vitro | Practolol (10 μM; 30 min) preferentially antagonizes the relaxant effects produced by R0363 in spontaneously contracted tracheal preparations from the guinea-pig[1]. Practolol (10 nM-100 μM) blocks the progesterone production induced by (-)epinephrine in a dose-dependent manner in granulosa cells[2]. |
In Vivo | Practolol (0.5 mg/kg; i.v.) decreases heart rate, left ventricular dP/dt max, myocardial blood flow and cardiac output in intact close-chest dogs[3]. Practolol (0.5 mg/kg; i.v.) decreases normal myocardial blood flow but flow in the ischaemic area remains unchanged after coronary artery ligation[3]. |
References |
Density | 1.0807 (rough estimate) |
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Boiling Point | 409.54°C (rough estimate) |
Melting Point | 134-136° (BuOAc) |
Molecular Formula | C14H22N2O3 |
Molecular Weight | 266.33600 |
Exact Mass | 266.16300 |
PSA | 70.59000 |
LogP | 1.84660 |
Index of Refraction | 1.5110 (estimate) |
Storage condition | 2-8°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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RIDADR | NONH for all modes of transport |
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RTECS | AE4222000 |
HS Code | 2924299090 |
~% Practolol CAS#:6673-35-4 |
Literature: Tetrahedron Asymmetry, , vol. 11, # 14 p. 2885 - 2898 |
~% Practolol CAS#:6673-35-4 |
Literature: Tetrahedron Asymmetry, , vol. 11, # 14 p. 2885 - 2898 |
HS Code | 2924299090 |
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Summary | 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
Large-Scale Prediction of Drug Targets Based on Local and Global Consistency of Chemical-Chemical Networks.
Comb. Chem. High Throughput Screen 19 , 121-8, (2016) It is crucial to identify the molecular targets of a compound during the course of the new drug discovery and drug development. Due to the complexity of biological systems, finding drug targets by bio... |
N-[4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl]acetamide |
rac Practolol |