Trehalose 6-behenate

Modify Date: 2024-01-12 17:21:26

Trehalose 6-behenate structure	Common Name	Trehalose 6-behenate
	CAS Number	66755-19-9	Molecular Weight	664.86
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₄H₆₄O₁₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Trehalose 6-behenate

Trehalose 6-behenate is a Th1/Th17 skewing vaccine adjuvant.

Name	Trehalose 6-behenate

Description	Trehalose 6-behenate is a Th1/Th17 skewing vaccine adjuvant.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
Target	Trehalose 6-behenate (TDB) exerts its effect through binding to the macrophage-inducible C-type lectin Mincle, a pathogen recognition receptor (PRR) that recognises pathogen-associated molecular patterns (PAMPs). The potential of Th1/Th17 skewing adjuvants in vaccine development provides a very real incentive for better definition of the structural motifs required for Mincle binding. Mincle is highly conserved between mice and humans, with 85 % protein similarity. In addition to being a receptor for TDMs, Trehalose 6-behenate (TDB), and the spliceosome-associated protein (SAP)130 (which activates Mincle at a binding site different to that involved in carbohydrate recognition), Mincle is also a receptor for Candida albicans, Malassezia, and Fonsecaea pedrosoi[1].
References	[1]. Stocker BL, et al. On one leg: trehalose monoesters activate macrophages in a Mincle-dependant manner. Chembiochem. 2014 Feb 10;15(3):382-8.

Molecular Formula	C₃₄H₆₄O₁₂
Molecular Weight	664.86

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Trehalose 6-behenate
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Purity: 98.0%
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