5'-O-Dimethoxytrityl-N-benzoyl-desoxycytidine

Modify Date: 2024-01-06 14:30:38

5'-O-Dimethoxytrityl-N-benzoyl-desoxycytidine Structure
5'-O-Dimethoxytrityl-N-benzoyl-desoxycytidine structure
Common Name 5'-O-Dimethoxytrityl-N-benzoyl-desoxycytidine
CAS Number 67219-55-0 Molecular Weight 633.69000
Density 1.27 g/cm3 Boiling Point N/A
Molecular Formula C37H35N3O7 Melting Point 119 °C
MSDS Chinese USA Flash Point N/A
Symbol GHS08
GHS08
Signal Word Danger

 Use of 5'-O-Dimethoxytrityl-N-benzoyl-desoxycytidine


N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine (5'-O-DMT-N4-Bz-dC) can be used for synthesis oligodeoxynucleotides containing a 3'-S-phosphorothiolate (3'-PS) linkage. N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine is an useful tool for probing enzyme-catalyzed cleavage processes in DNA[1].

 Names

Name N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine
Synonym More Synonyms

  Biological Activity

Description N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine (5'-O-DMT-N4-Bz-dC) can be used for synthesis oligodeoxynucleotides containing a 3'-S-phosphorothiolate (3'-PS) linkage. N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine is an useful tool for probing enzyme-catalyzed cleavage processes in DNA[1].
Related Catalog
References

[1]. James W Gaynor, et al. Synthesis of the 3'-thio-nucleosides and subsequent automated synthesis of oligodeoxynucleotides containing a 3'-S-phosphorothiolate linkage. Nat Protoc. 2007;2(12):3122-35.

 Chemical & Physical Properties

Density 1.27 g/cm3
Melting Point 119 °C
Molecular Formula C37H35N3O7
Molecular Weight 633.69000
Exact Mass 633.24800
PSA 121.14000
LogP 5.24290
Index of Refraction 58 ° (C=1, MeOH)
Storage condition −20°C

 Safety Information

Symbol GHS08
GHS08
Signal Word Danger
Hazard Statements H340-H350
Precautionary Statements P201-P280-P308 + P313
Personal Protective Equipment Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes Xn: Harmful;
Risk Phrases R40
Safety Phrases S36/37
RIDADR NONH for all modes of transport
WGK Germany 1

 Synthetic Route

 Articles2

More Articles
Diels-Alder cycloadditions in water for the straightforward preparation of peptide-oligonucleotide conjugates.

Nucleic Acids Res. 34(3) , e24, (2006)

The Diels-Alder reaction between diene-modified oligonucleotides and maleimide-derivatized peptides afforded peptide-oligonucleotide conjugates with high purity and yield. Synthesis of the reagents wa...

Aldrichimica Acta 20 , 52, (1987)

 Synonyms

N-[1-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxyoxolan-2-yl]-2-oxopyrimidin-4-yl]benzamide
EINECS 266-605-9
MFCD00010114
5'-O-Dimethoxytrityl-N-benzoyl-desoxycytidine
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