Bevenopran

Modify Date: 2024-01-12 19:17:01

Bevenopran Structure
Bevenopran structure
Common Name Bevenopran
CAS Number 676500-67-7 Molecular Weight 386.44500
Density N/A Boiling Point N/A
Molecular Formula C20H26N4O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Bevenopran


Bevenopran is a peripheral μ-opioid receptor antagonist.

 Names

Name 5-[2-methoxy-4-[[2-(oxan-4-yl)ethylamino]methyl]phenoxy]pyrazine-2-carboxamide
Synonym More Synonyms

 Bevenopran Biological Activity

Description Bevenopran is a peripheral μ-opioid receptor antagonist.
Related Catalog
Target

μ-opioid receptor[1]

In Vivo Bevenopran is a peripheral μ-opioid receptor antagonist. Bevenopran is currently under investigation for the treatment of opioid-induced bowel dysfunction (OBD)[1]. Bevenopran tends to increase bowel movement (BM) frequency, especially for 0.1 mg twice daily and 4 mg daily, respectively[1].
References

[1]. Diego L, et al. Novel opioid antagonists for opioid-induced bowel dysfunction. Expert Opin Investig Drugs. 2011 Aug;20(8):1047-56.

[2]. Siemens W, et al. Advances in pharmacotherapy for opioid-induced constipation - a systematic review. Expert Opin Pharmacother. 2015 Mar;16(4):515-32.

 Chemical & Physical Properties

Molecular Formula C20H26N4O4
Molecular Weight 386.44500
Exact Mass 386.19500
PSA 109.58000
LogP 3.55780
Storage condition 2-8℃

 Synonyms

UNII-IC58Q2EHPJ
CB5945
Bevenopran
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