Mcl-1-Puma inhibitor 8

Modify Date: 2024-01-16 20:16:00

Mcl-1-Puma inhibitor 8 Structure
Mcl-1-Puma inhibitor 8 structure
Common Name Mcl-1-Puma inhibitor 8
CAS Number 678158-55-9 Molecular Weight 393.50
Density N/A Boiling Point N/A
Molecular Formula C22H23N3O2S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Mcl-1-Puma inhibitor 8


Mcl1-IN-8 (Comp8) is a Mcl-1-PUMA interface inhibitor, with a Ki of 0.3 μM. Mcl1-IN-8 (Comp8) exhibits dual activity on reduce PUMA-dependent apoptosis while deactivating Mcl-1-mediated anti-apoptosis in cancer cells[1].

 Names

Name Mcl1-IN-8

 Mcl-1-Puma inhibitor 8 Biological Activity

Description Mcl1-IN-8 (Comp8) is a Mcl-1-PUMA interface inhibitor, with a Ki of 0.3 μM. Mcl1-IN-8 (Comp8) exhibits dual activity on reduce PUMA-dependent apoptosis while deactivating Mcl-1-mediated anti-apoptosis in cancer cells[1].
Related Catalog
Target

Mcl-1:0.3 μM (Ki)

References

[1]. Liu J, et al. Targeting the apoptotic Mcl-1-PUMA interface with a dual-acting compound. Oncotarget. 2017 Apr 20;8(33):54236-54242.

 Chemical & Physical Properties

Molecular Formula C22H23N3O2S
Molecular Weight 393.50
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