Vitamin B12

Modify Date: 2024-01-02 18:01:04

Vitamin B12 Structure
Vitamin B12 structure
 Common Name Vitamin B12
CAS Number 68-19-9 Molecular Weight 1355.365
Density N/A Boiling Point N/A
Molecular Formula C63H88CoN14O14P Melting Point >300ºC
MSDS Chinese USA Flash Point 48.2 °F
Symbol GHS02 GHS06 GHS08
GHS02, GHS06, GHS08		 Signal Word Danger

 Use of Vitamin B12


Vitamin B12 is a water soluble vitamin with a key role in the normal functioning of the brain and nervous system, and for the formation of blood.Target: OthersVitamin B12 is a water-soluble vitamin with a key role in the normal functioning of the brain and nervous system, and for the formation of blood. It is one of the eight B vitamins. It is normally involved in the metabolism of every cell of the human body, especially affecting DNA synthesis and regulation, but also fatty acid synthesis (especially odd chain fatty acids) and energy production. Vitamin B12 normally plays a significant role in the metabolism of every cell of the body, especially affecting the DNA synthesis and regulation but also fatty acid synthesis and energy production. However, many (though not all) of the effects of functions of B12 can be replaced by sufficient quantities of folic acid (vitamin B9), since B12 is used to regenerate folate in the body. Most vitamin B12 deficiency symptoms are actually folate deficiency symptoms, since they include all the effects of pernicious anemia and megaloblastosis, which are due to poor synthesis of DNA when the body does not have a proper supply of folic acid for the production of thymine due to methyl trapping. When sufficient folic acid is available, all known B12 related deficiency syndromes normalize, save those narrowly connected with the vitamin B12-dependent enzymes Methylmalonyl Coenzyme A mutase, and 5-methyltetrahydrofolate-homocysteine methyltransferase (MTR), also known as methionine synthase; and the buildup of their respective substrates (methylmalonic acid, MMA) and homocysteine.Coenzyme B12's reactive C-Co bond participates in three main types of enzyme-catalyzed reactions [1, 2].

 Names

Name cyanocob(III)alamin
Synonym More Synonyms

 Vitamin B12 Biological Activity

Description Vitamin B12 is a water soluble vitamin with a key role in the normal functioning of the brain and nervous system, and for the formation of blood.Target: OthersVitamin B12 is a water-soluble vitamin with a key role in the normal functioning of the brain and nervous system, and for the formation of blood. It is one of the eight B vitamins. It is normally involved in the metabolism of every cell of the human body, especially affecting DNA synthesis and regulation, but also fatty acid synthesis (especially odd chain fatty acids) and energy production. Vitamin B12 normally plays a significant role in the metabolism of every cell of the body, especially affecting the DNA synthesis and regulation but also fatty acid synthesis and energy production. However, many (though not all) of the effects of functions of B12 can be replaced by sufficient quantities of folic acid (vitamin B9), since B12 is used to regenerate folate in the body. Most vitamin B12 deficiency symptoms are actually folate deficiency symptoms, since they include all the effects of pernicious anemia and megaloblastosis, which are due to poor synthesis of DNA when the body does not have a proper supply of folic acid for the production of thymine due to methyl trapping. When sufficient folic acid is available, all known B12 related deficiency syndromes normalize, save those narrowly connected with the vitamin B12-dependent enzymes Methylmalonyl Coenzyme A mutase, and 5-methyltetrahydrofolate-homocysteine methyltransferase (MTR), also known as methionine synthase; and the buildup of their respective substrates (methylmalonic acid, MMA) and homocysteine.Coenzyme B12's reactive C-Co bond participates in three main types of enzyme-catalyzed reactions [1, 2].
Related Catalog
References

[1]. http://en.wikipedia.org/wiki/Vitamin_B12

[2]. Banerjee, R. and S.W. Ragsdale, The many faces of vitamin B12: catalysis by cobalamin-dependent enzymes. Annu Rev Biochem, 2003. 72: p. 209-47.

 Chemical & Physical Properties

Melting Point >300ºC
Molecular Formula C63H88CoN14O14P
Molecular Weight 1355.365
Exact Mass 1354.567383
PSA 479.70000
LogP 6.57018

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GG3750000
CHEMICAL NAME :
Cobinamide, cyanide phosphate 3'-ester with 5,6-dimethyl-1-alpha-D- ribofuranosylbenzimidazole, inner salt
CAS REGISTRY NUMBER :
68-19-9
LAST UPDATED :
199706
DATA ITEMS CITED :
11
MOLECULAR FORMULA :
C63-H88-Co-N14-O14-P
MOLECULAR WEIGHT :
1355.55
WISWESSER LINE NOTATION :
D C5656 B-5 B6 B5 S5 J&5 B-19- Q&6 N&5/B-N/DU/J&-M& J&- O& 9ABBBBCSTT V& AN-CO-&& B-N CN TN C

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 42,114,1992
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1364 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - excitement
REFERENCE :
ARPAAQ Archives of Pathology. (Chicago, IL) V.5(3)-50(3), 1928-50; V.70-99, 1960-75. For publisher information, see APLMAS. Volume(issue)/page/year: 49,278,1950
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2727 ug/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - chronic pulmonary edema Blood - other changes
REFERENCE :
ARPAAQ Archives of Pathology. (Chicago, IL) V.5(3)-50(3), 1928-50; V.70-99, 1960-75. For publisher information, see APLMAS. Volume(issue)/page/year: 49,278,1950 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
115 mg/kg
SEX/DURATION :
female 1-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 242,263,1973
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
DOSE :
168 mg/kg
SEX/DURATION :
female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 67,377,1978
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
DOSE :
84 mg/kg
SEX/DURATION :
female 11 day(s) after conception
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 67,377,1978 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO COBALT METAL, dust and fume-air:10H TWA 0.05 mg/m3 REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80358 No. of Facilities: 1219 (estimated) No. of Industries: 6 No. of Occupations: 20 No. of Employees: 19601 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80358 No. of Facilities: 3495 (estimated) No. of Industries: 12 No. of Occupations: 46 No. of Employees: 65178 (estimated) No. of Female Employees: 27980 (estimated)

 Safety Information

Symbol GHS02 GHS06 GHS08
GHS02, GHS06, GHS08
Signal Word Danger
Hazard Statements H225-H301 + H311 + H331-H370
Precautionary Statements P210-P260-P280-P301 + P310-P311
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes F,T
Risk Phrases 11-23/24/25-39/23/24/25
Safety Phrases S24/25
RIDADR UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany 1
RTECS GG3750000
HS Code 2936260000
Flash Point(F) 48.2 °F
Flash Point(C) 9 °C

 Precursor & DownStream

Precursor  0

DownStream  2

 Customs

HS Code 2936260000

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 Synonyms

cob(II)alamin
vitral
Vb12
cotel
vibalt
embiol
Vitamin b12
Cyanocobalamin
CN-13-epiCbl
covit
cn-b12
vitamin B-12
cyomin
EINECS 200-680-0
MFCD00151092
Bedoz
CN-CBL
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Chemsrc provides Vitamin B12(CAS#:68-19-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Vitamin B12 are included as well.>> amp version: Vitamin B12

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