6,8-diprenylnaringenin

Modify Date: 2024-01-04 00:39:10

6,8-diprenylnaringenin Structure
6,8-diprenylnaringenin structure
Common Name 6,8-diprenylnaringenin
CAS Number 68236-11-3 Molecular Weight 408.48700
Density 1.22g/cm3 Boiling Point 639.245°C at 760 mmHg
Molecular Formula C25H28O5 Melting Point N/A
MSDS N/A Flash Point 218.297°C

 Use of 6,8-diprenylnaringenin


6,8-Diprenylnaringenin (Lonchocarpol A; Senegalensin), a hop prenylflavonoid, is a inhibitor of breast cancer resistance protein (BCRP/ABCG2). 6,8-Diprenylnaringenin inhibits ABCG2-mediated efflux of Mitoxantrone, and 3H-Methotrexate transport (IC50=0.41 μM) in HEK293 cells. 6,8-Diprenylnaringenin exhibits some estrogenicity, but its potency is less than 1% of that of 8-Prenylnaringenin[1][2].

 Names

Name 6,8-diprenylnaringenin
Synonym More Synonyms

 6,8-diprenylnaringenin Biological Activity

Description 6,8-Diprenylnaringenin (Lonchocarpol A; Senegalensin), a hop prenylflavonoid, is a inhibitor of breast cancer resistance protein (BCRP/ABCG2). 6,8-Diprenylnaringenin inhibits ABCG2-mediated efflux of Mitoxantrone, and 3H-Methotrexate transport (IC50=0.41 μM) in HEK293 cells. 6,8-Diprenylnaringenin exhibits some estrogenicity, but its potency is less than 1% of that of 8-Prenylnaringenin[1][2].
Related Catalog
References

[1]. Tan KW, et al. Hop-derived prenylflavonoids are substrates and inhibitors of the efflux transporter breast cancer resistance protein (BCRP/ABCG2). Mol Nutr Food Res. 2014 Nov;58(11):2099-110.

[2]. Milligan SR, et al. The endocrine activities of 8-prenylnaringenin and related hop (Humulus lupulus L.) flavonoids. J Clin Endocrinol Metab. 2000 Dec;85(12):4912-5.

 Chemical & Physical Properties

Density 1.22g/cm3
Boiling Point 639.245°C at 760 mmHg
Molecular Formula C25H28O5
Molecular Weight 408.48700
Flash Point 218.297°C
Exact Mass 408.19400
PSA 86.99000
LogP 5.52730

 Synonyms

Senegalensien
Lonchocarpol A
(2S)-5,7-dihydroxy-2-(4-hydroxyphenyl)-6,8-bis(3-methylbut-2-enyl)-2,3-dihydrochromen-4-one
Senegalensein
Senegalensin
4H-1-Benzopyran-4-one,2,3-dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-6,8-bis(3-methyl-2-butenyl)-,(S)
6,8-Diprenylnaringenin
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