Asimilobine
Modify Date: 2024-01-17 16:34:02
Asimilobine structure
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Common Name | Asimilobine | ||
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| CAS Number | 6871-21-2 | Molecular Weight | 267.322 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 472.5±45.0 °C at 760 mmHg | |
| Molecular Formula | C17H17NO2 | Melting Point | 177-179℃ (acetone ) | |
| MSDS | N/A | Flash Point | 239.6±28.7 °C | |
Use of AsimilobineAsimilobine is an aporphine isoquinoline alkaloid isolated from plant species of Magnolia obobata Thun. Asimilobine is a dopamine biosynthesis inhibitor and a serotonergic receptor antagonist. Asimilobine shows an antimalarial and anti-cancer activity[1][2]. |
| Name | (R)-1-methoxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-2-ol |
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| Synonym | More Synonyms |
| Description | Asimilobine is an aporphine isoquinoline alkaloid isolated from plant species of Magnolia obobata Thun. Asimilobine is a dopamine biosynthesis inhibitor and a serotonergic receptor antagonist. Asimilobine shows an antimalarial and anti-cancer activity[1][2]. |
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| Related Catalog | |
| Target |
Dopamine Receptor serotonergic receptor |
| In Vitro | Asimilobine (0.05-0.2 μM; for 24 h) shows a significant inhibition of intracellular dopamine levels in a concentration-dependent manner with an IC50 value of 0.13 μM[2]. Asimilobine (0.15 μM) inhibits tyrosine hydroxylase (TH) and aromatic L-amino acid decarboxylase (AADC) activities at 24 h[2]. Asimilobine also decreases TH mRNA levels and intracellular cyclic AMP levels[2]. |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 472.5±45.0 °C at 760 mmHg |
| Melting Point | 177-179℃ (acetone ) |
| Molecular Formula | C17H17NO2 |
| Molecular Weight | 267.322 |
| Flash Point | 239.6±28.7 °C |
| Exact Mass | 267.125916 |
| PSA | 41.49000 |
| LogP | 2.46 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.638 |
| Hazard Codes | Xi |
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| Asimilobine |
| 4H-Dibenzo(de,g)quinolin-2-ol, 5,6,6a,7-tetrahydro-1-methoxy-, (R)- |
| 4H-Dibenzo[de,g]quinolin-2-ol, 5,6,6a,7-tetrahydro-1-methoxy-, (6aR)- |
| (6aR)-1-Methoxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-2-ol |