4-(Hydroxymethyl)phenoxyacetic acid

Modify Date: 2024-01-02 21:52:21

4-(Hydroxymethyl)phenoxyacetic acid Structure
4-(Hydroxymethyl)phenoxyacetic acid structure
Common Name 4-(Hydroxymethyl)phenoxyacetic acid
CAS Number 68858-21-9 Molecular Weight 182.173
Density 1.3±0.1 g/cm3 Boiling Point 378.3±22.0 °C at 760 mmHg
Molecular Formula C9H10O4 Melting Point 112-114 °C
MSDS Chinese USA Flash Point 156.3±15.8 °C

 Use of 4-(Hydroxymethyl)phenoxyacetic acid


4-(Hydroxymethyl)phenoxyacetic acid is an acid-labile resin linkage agent for use in solid phase peptide synthesis[1].

 Names

Name 4-(Hydroxymethyl)phenoxyacetic acid
Synonym More Synonyms

 4-(Hydroxymethyl)phenoxyacetic acid Biological Activity

Description 4-(Hydroxymethyl)phenoxyacetic acid is an acid-labile resin linkage agent for use in solid phase peptide synthesis[1].
Related Catalog
References

[1]. C T Bui, et al. Improving the performance of an acid-labile 4-hydroxymethyl phenoxyacetic acid (HMP) linker on resin and SynPhase grafted solid-supports. J Pept Sci. 2000 Oct;6(10):534-8.  

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 378.3±22.0 °C at 760 mmHg
Melting Point 112-114 °C
Molecular Formula C9H10O4
Molecular Weight 182.173
Flash Point 156.3±15.8 °C
Exact Mass 182.057907
PSA 66.76000
LogP 0.16
Vapour Pressure 0.0±0.9 mmHg at 25°C
Index of Refraction 1.573
Storage condition 2-8°C

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases S22-S24/25
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2918990090

 Synthetic Route

~54%

4-(Hydroxymethyl)phenoxyacetic acid Structure

4-(Hydroxymethy...

CAS#:68858-21-9

Literature: Atherton, Eric; Logan, Christopher J.; Sheppard, Robert C. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 538 - 546

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4-(Hydroxymethyl)phenoxyacetic acid Structure

4-(Hydroxymethy...

CAS#:68858-21-9

Literature: US5187270 A1, ;

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4-(Hydroxymethyl)phenoxyacetic acid Structure

4-(Hydroxymethy...

CAS#:68858-21-9

Literature: Bioorganic and Medicinal Chemistry, , vol. 16, # 23 p. 10049 - 10060

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4-(Hydroxymethyl)phenoxyacetic acid Structure

4-(Hydroxymethy...

CAS#:68858-21-9

Literature: Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 538 - 546

 Customs

HS Code 2918990090
Summary 2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Articles5

More Articles
Acid-labile resin linkage agents for use in solid phase peptide synthesis.

Int. J. Pept. Protein Res. 20(5) , 451-4, (1982)

Details are given of the preparation of two acid-labile peptide-resin linkage agents for use in solid phase peptide synthesis, viz. 4-hydroxymethylphenoxy-acetic acid and 3-methoxy-4-hydroxymethylphen...

Improving the performance of an acid-labile 4-hydroxymethyl phenoxyacetic acid (HMP) linker on resin and SynPhase grafted solid-supports.

J. Pept. Sci. 6(10) , 534-8, (2000)

A replacement of the acetic acid moiety by valeric acid within the 4-hydroxymethylphenoxyacetic acid (HMP) linker (Sheppard RC, Williams BJ. Acid-labile resin linkage agents for use in solid phase pep...

E. Atherton et al.

J. Chem. Soc. Chem. Commun. , 537, (1978)

 Synonyms

HMP Linker
Acetic acid, 2-[4-(hydroxymethyl)phenoxy]-
HMPLinker
2-[4-(hydroxymethyl)phenoxy]acetic acid
[4-(Hydroxymethyl)phenoxy]acetic acid
MFCD00057827
EINECS 229-560-6
HMP-Linker
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