toltrazuril

Modify Date: 2024-01-03 10:35:28

toltrazuril Structure
toltrazuril structure
 Common Name toltrazuril
CAS Number 69004-03-1 Molecular Weight 425.382
Density 1.5±0.1 g/cm3 Boiling Point N/A
Molecular Formula C18H14F3N3O4S Melting Point 194-196°C
MSDS Chinese USA Flash Point N/A
Symbol GHS09
GHS09		 Signal Word Warning

 Use of toltrazuril


Toltrazuril is an antiprotozoal agent that acts upon Coccidia parasites.Target: AntiparasiticToltrazuril is an antiprotozoal agent that acts upon Coccidia parasites. Toltrazuril induces changes in the fine structure of coccidian development stages that are mainly due to a swelling of the endoplasmatic reticulum and of the Golgi apparatus and to abnormalities in the peri-nuclear space, disturbance in nuclear division. Treated with toltrazuril showed a considerably lower mean opg to that of group C (5.78 opg versus 144.62 opg) (p < 0.05) and a FOCR of 97.7 %. The higher efficacy (99.23 %) was observed at 15 days post treatment; however, the average efficacy of the drug remained extremely high (> 90 %) for all the study.

 Names

Name Toltrazuril
Synonym More Synonyms

 toltrazuril Biological Activity

Description Toltrazuril is an antiprotozoal agent that acts upon Coccidia parasites.Target: AntiparasiticToltrazuril is an antiprotozoal agent that acts upon Coccidia parasites. Toltrazuril induces changes in the fine structure of coccidian development stages that are mainly due to a swelling of the endoplasmatic reticulum and of the Golgi apparatus and to abnormalities in the peri-nuclear space, disturbance in nuclear division. Treated with toltrazuril showed a considerably lower mean opg to that of group C (5.78 opg versus 144.62 opg) (p < 0.05) and a FOCR of 97.7 %. The higher efficacy (99.23 %) was observed at 15 days post treatment; however, the average efficacy of the drug remained extremely high (> 90 %) for all the study.
Related Catalog
References

[1]. Mehlhorn H, et al. Toltrazuril effective against a broad spectrum of protozoan parasites. Parasitol Res. 1988;75(1):64-6.

[2]. Diaferia M, et al. Efficacy of toltrazuril 5 % suspension (Baycox?, Bayer) and diclazuril (Vecoxan, Janssen-Cilag) in the control of Eimeria spp. in lambs. Parasitol Res. 2013 Aug;112 Suppl 1:163-8.

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Melting Point 194-196°C
Molecular Formula C18H14F3N3O4S
Molecular Weight 425.382
Exact Mass 425.065704
PSA 111.39000
LogP 2.90
Index of Refraction 1.640
Storage condition 0-6°C

 Safety Information

Symbol GHS09
GHS09
Signal Word Warning
Hazard Statements H410
Precautionary Statements P273-P501
Personal Protective Equipment Eyeshields;Faceshields;Gloves
Hazard Codes N:Dangerousfortheenvironment;
Risk Phrases R50/53
Safety Phrases S60-S61
RIDADR UN 3077
HS Code 2933699090

 Synthetic Route

1-methyl-5-[3-methyl-4-(4-trifluoromethylthiophenoxy)-phenyl]-biuret structure

1-methyl-5-[3-m...

CAS#:106310-17-2

Ethyl carbonate structure

Ethyl carbonate

CAS#:105-58-8

~%

toltrazuril Structure

toltrazuril

CAS#:69004-03-1

Literature: US4874860 A1, ; US4898979 A1, ;
3-methyl-5-[3-methyl-4-(4-trifluoromethylthiophenoxy)-phenyl]-biuret structure

3-methyl-5-[3-m...

CAS#:106310-18-3

Ethyl carbonate structure

Ethyl carbonate

CAS#:105-58-8

~%

toltrazuril Structure

toltrazuril

CAS#:69004-03-1

Literature: US4874860 A1, ; US4898979 A1, ;

 Customs

HS Code 2933699090
Summary 2933699090 other compounds containing an unfused triazine ring (whether or not hydrogenated) in the structure。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:20.0%

 Articles27

More Articles
Pharmacokinetics and improved bioavailability of toltrazuril after oral administration to rabbits.

J. Vet. Pharmacol. Ther. 33(5) , 503-6, (2010)

Necrotic enteritis due to simultaneous infection with Isospora suis and clostridia in newborn piglets and its prevention by early treatment with toltrazuril.

Parasitol. Res. 110(4) , 1347-55, (2012)

In this study, 51 piglets originating from five different sows were included in the investigations. The animal source of all sows had a history of Clostridium perfringens type A (β2) infection. The pi...

Determination of diclazuril, toltrazuril and its two metabolites in poultry tissues and eggs by gel permeation chromatography-liquid chromatography-tandem mass spectrometry.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 879(20) , 1757-63, (2011)

A new procedure has been described for the extraction of diclazuril (DIZ), toltrazuril (TOZ) and its two main metabolites toltrazuril sulphoxide (TZSO) and toltrazuril sulphone (TZS) from poultry tiss...

 Synonyms

1-methyl-3-[3-methyl-4-[4-(trifluoromethylsulfanyl)phenoxy]phenyl]-1,3,5-triazinane-2,4,6-trione
1-Methyl-3-(3-methyl-4-{4-[(trifluoromethyl)sulfanyl]phenoxy}phenyl)-1,3,5-triazinane-2,4,6-trione
Bay Vi 9142
MFCD00867201
1-Methyl-3-[4-[p-[(trifluoromethyl)thio]phenoxy]-m-tolyl]-s-triazine-2,4,6(1H,3H,5H)-trione
1,3,5-Triazine-2,4,6(1H,3H,5H)-trione, 1-methyl-3-[3-methyl-4-[4-[(trifluoromethyl)thio]phenoxy]phenyl]-
Toltrazuril
EINECS 231-710-0
1-Methyl-3-[3-methyl-4-[4-[(trifluoromethyl)thio]phenoxy]phenyl]-1,3,5-triazine-2,4,6(1H,3H,5H)-trione
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Chemsrc provides toltrazuril(CAS#:69004-03-1) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of toltrazuril are included as well.>> amp version: toltrazuril

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