![]() ZIO 101 structure
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Common Name | ZIO 101 | ||
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CAS Number | 69819-86-9 | Molecular Weight | 411.30600 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C12H22AsN3O6S | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of ZIO 101Darinaparsin (ZIO-101), an organic arsenical, is a mitochondrial-targeted agent. Darinaparsin induces apoptosis in ancer cells, and has anticancer effects[1]. |
Name | (2S)-2-amino-5-[[(2R)-1-(carboxymethylamino)-3-dimethylarsanylsulfanyl-1-oxopropan-2-yl]amino]-5-oxopentanoic acid |
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Synonym | More Synonyms |
Description | Darinaparsin (ZIO-101), an organic arsenical, is a mitochondrial-targeted agent. Darinaparsin induces apoptosis in ancer cells, and has anticancer effects[1]. |
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Related Catalog | |
In Vitro | Darinaparsin is cytotoxic to prostate cancer cell lines as well as fresh prostate cancer cells at low micromolar concentrations, and importantly inhibits the termed tumor-initiating cells (TIC) subpopulations[1]. |
In Vivo | Darinaparsin inhibits growth of the castrate-resistant Du145 prostate tumor propagated as xenograft in mice and inhibits the tumor-initiating potential of prostate cancer cells[1]. |
References |
Molecular Formula | C12H22AsN3O6S |
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Molecular Weight | 411.30600 |
Exact Mass | 411.04500 |
PSA | 191.10000 |
LogP | 1.22930 |
Darinaparsin |
ZIO-101-C |
UNII-9XX54M675G |
Zinapar |
SGLU1 |
ZIO-101 |
SP-02L |
Darinaparsin (USAN) |
DMAs(III)G |