Methyl Gerfelin

Modify Date: 2024-01-11 15:28:19

Methyl Gerfelin structure	Common Name	Methyl Gerfelin
	CAS Number	700870-56-0	Molecular Weight	304.29500
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₆H₁₆O₆	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Methyl Gerfelin

Methyl gerfelin inhibits osteoclast differentiation by binding 3 major cellular proteins: glyoxalase 1 (GLO1), sterol binding protein 2 (SCP2), and small glutamine-rich tetratricopeptide repeat containing protein A (SGTA). Methyl gerfelin is a potent GLO1 inhibitor related to the flavonoid class[1][2].

Name	methyl 4-(2,3-dihydroxy-5-methylphenoxy)-2-hydroxy-6-methylbenzoate
Synonym	More Synonyms

Description	Methyl gerfelin inhibits osteoclast differentiation by binding 3 major cellular proteins: glyoxalase 1 (GLO1), sterol binding protein 2 (SCP2), and small glutamine-rich tetratricopeptide repeat containing protein A (SGTA). Methyl gerfelin is a potent GLO1 inhibitor related to the flavonoid class[1][2].
Related Catalog	Research Areas >> Others
Target	Glyoxalase 1 (GLO1), Sterol binding protein 2 (SCP2), Small glutamine-rich tetratricopeptide repeat containing protein A (SGTA)[1]
In Vitro	Methyl gerfelin (0-30 μM; 72 h) 抑制破骨细胞形成，IC50 为 2.8 μM，有效浓度下不影响成熟破骨细胞存活和功能[1]。
References	[1]. Kanoh N, et al. Dual structure-activity relationship of osteoclastogenesis inhibitor methyl gerfelin based on TEG scanning. Bioconjug Chem. 2013 Jan 16;24(1):44-52. [2]. Perez C, et al. Metal-Binding Pharmacophore Library Yields the Discovery of a Glyoxalase 1 Inhibitor. J Med Chem. 2019 Feb 14;62(3):1609-1625.