700870-56-0

700870-56-0 structure

Name: Methyl Gerfelin
Chemical Name: methyl 4-(2,3-dihydroxy-5-methylphenoxy)-2-hydroxy-6-methylbenzoate
CAS Number: 700870-56-0
Molecular Formula: C₁₆H₁₆O₆
Molecular Weight: 304.29500
Catalog: Research Areas Others
Create Date: 2017-06-02 05:36:58
Modify Date: 2024-01-11 15:28:19
Methyl gerfelin inhibits osteoclast differentiation by binding 3 major cellular proteins: glyoxalase 1 (GLO1), sterol binding protein 2 (SCP2), and small glutamine-rich tetratricopeptide repeat containing protein A (SGTA). Methyl gerfelin is a potent GLO1 inhibitor related to the flavonoid class[1][2].

Name	methyl 4-(2,3-dihydroxy-5-methylphenoxy)-2-hydroxy-6-methylbenzoate
Synonyms	Gerfelin methyl MGI 2za0 Methyl Gerfelin

Description	Methyl gerfelin inhibits osteoclast differentiation by binding 3 major cellular proteins: glyoxalase 1 (GLO1), sterol binding protein 2 (SCP2), and small glutamine-rich tetratricopeptide repeat containing protein A (SGTA). Methyl gerfelin is a potent GLO1 inhibitor related to the flavonoid class[1][2].
Related Catalog	Research Areas >> Others
Target	Glyoxalase 1 (GLO1), Sterol binding protein 2 (SCP2), Small glutamine-rich tetratricopeptide repeat containing protein A (SGTA)[1]
In Vitro	Methyl gerfelin (0-30 μM; 72 h) 抑制破骨细胞形成，IC50 为 2.8 μM，有效浓度下不影响成熟破骨细胞存活和功能[1]。
References	[1]. Kanoh N, et al. Dual structure-activity relationship of osteoclastogenesis inhibitor methyl gerfelin based on TEG scanning. Bioconjug Chem. 2013 Jan 16;24(1):44-52. [2]. Perez C, et al. Metal-Binding Pharmacophore Library Yields the Discovery of a Glyoxalase 1 Inhibitor. J Med Chem. 2019 Feb 14;62(3):1609-1625.